The likes of Declan Rice and Michail Antonio are aiming for the first major trophies of their careers, while as a club the Hammers are hoping to end over four decades of waiting to see silverware lifted with their ribbon colours attached.
Fiorentina finished in the top half of Serie A this season so will present a huge test - West Ham came 14th in England - but La Viola have themselves gone more than 20 years without a big trophy too.
In Prague, one of those clubs will end their long waits and their fans will have a celebration for the ages; the other will be left to wonder what might have been, and have to get ready to do it all again next year. Here’s everything you need to know ahead of the final.
When is the match?
The final kicks off at 8pm (UK) on Wednesday 7 June.
Where can I watch it?
The match will be shown live on BT Sport 1 and BT Sport Ultimate. It can also be streamed on the BT Sport website, BT Sport app and for free on the BT Sport YouTube channel.
What is the team news?
Gianluca Scamacca misses the final after having knee surgery but otherwise, the Hammers should have a full squad to choose from.
What are the confirmed lineups?
West Ham 37/20
The Hammers to bring home a long-awaited trophy. West Ham 2-1 Fiorentina