Washington at USC football: Predictions, odds, how to watch Pac-12 showdown in Los Angeles

The final season of Pac-12 football features some of the best matchups in the country and Week 10 is no different. The No. 5 Washington Huskies travel to Southern California to take on the No. 22 USC Trojans in a what could be another high-scoring Pac-12 game this fall.

Washington's been one of the stories of the season through two months of action. Huskies quarterback and Heisman frontrunner Michael Penix Jr. leads the most prolific passing attack in the country averaging nearly 400 yards through the air per game. His 2,945 passing yards through eight games leads the nation and his 24 touchdowns rank third as well.

The Huskies' dynamic offense powered them to at least 30 points through each of the first six games of the season. Washington racked up wins quickly: 56-19 over Boise State, 43-10 over Tulsa, 41-7 over Michigan State, 59-32 over Cal, 31-24 over Arizona, and 36-33 over Oregon. The win against Oregon came down to a missed field goal by the Ducks as time expired.

Pac-12 showdown: No. 5 Washington, No. 24 USC both embrace chance to do something special

After that Oregon win, Washington eked out a 15-7 win over Arizona State at home and outlasted Stanford 42-33 on the road last week. Both were far cries from the double-digit wins the Huskies posted weekly early on in the season.

“Every win is hard, especially when you get to conference play and teams can do a good job of trying to see what it is they need to try to do to slow you down," Washington coach Kalen DeBoer said. "We’re doing the same for the teams that we play. So yeah, I think every season that I’ve been a part of, there’s very few where it’s just been this clean, easy ride throughout the course of the year.”

This week, the Huskies take on a Trojans team making its way through an up-and-down 2023 season.

Week 10 ACC action: Florida State's visit to Pitt, Virginia Tech at Louisville highlight slate of games

USC started off hot with four double-digit wins to start the season. A 56-28 win over San Jose State in the opener preceded a 66-14 win against Nevada, 56-10 victory over Stanford, and a 42-28 win over Arizona State.

Reigning Heisman Trophy winner Caleb Williams pushed the Trojans offense to great heights in that four-game stretch, averaging more than four touchdowns a game.

The Trojans won their next two games. A 48-41 win over Colorado on the road kept the Trojans perfect despite a late comeback attempt by the Buffaloes. A week later, Williams scored on three overtime possessions to push USC past Arizona 43-41 at home.

Stars under center: High-powered offenses featuring elite QBs clash when No. 5 Washington heads to No. 24 USC

“You don’t want to put yourself in that hole,” USC coach Lincoln Riley said after that overtime win. "But when you’re in it, you can feel sorry for yourself or you can dig yourself out.”

The next week, USC dug a hole they couldn't get out from. Notre Dame knocked off the Trojans 48-20 and forced Williams into the first three-interception game of his college career. A week later, Utah continued its run of wins against USC with a 34-32 victory in Los Angeles to hand Riley his first home loss as Trojans head coach.

The Trojans got back on track last week with an incredibly tight 50-49 win over Cal in Berkeley.

"The last two weeks, things haven’t went our way," Riley said. "To step up here on the road and go find a way to get this sucker done was huge. There’s a lot to build on and there’s a lot that needs to improve.”

Postseason form: No. 5 Washington faces a challenging final month that will prove if the Huskies are playoff worthy

The two teams meet with different objectives for the win. Washington needs a win ahead of games against more ranked teams in the Pac-12. Staying perfect improves the Huskies' chance at making the College Football Playoff. USC, by contrast, needs a win to keep up with the Huskies and Oregon at the top of the conference standings.

Washington at USC predictions roundup

Sportsbook Wire: Washington 45, USC 40

Payton Shanks writes, "USC has been on a rough stretch recently, losing 2 of its last 3 games, and Washington will be its toughest test to date... USC’s defense will have no success stopping this Huskies offense and that will be the reason the Trojans lose once again."

Fox Sports: Over 76 points combined

Geoff Schwatrz writes, "I know USC isn’t playing its best football lately, but we know it can score against Washington... the Huskies are not going to stop USC in this game, meaning the over is absolutely the play."

ESPN: USC has a 54% chance of victory at home against Washington

ESPN's Football Power Index (FPI) rank the Trojans at 15.1, just below the Huskies in the power rankings at 16.8. Washington's recent struggles and close games on the road give the analytics a slight edge to the Trojans in this one.

College Football HQ: Washington 45-41

James Parks says, "Penix and Williams will both pile up yards and throw their receivers open in the deeper third of the field with some regularity, but between these two units, one has been far more generous to opponents than the other: the Trojans."

Athlon Sports: Washington 36, USC 33

Staff writes, "USC covered eight times in 14 matchups with a spread last season."

Pac-12 showdown and SEC clashes: The 7 biggest games of Week 10 in college football

How to Watch Washington at USC: TV channel and streaming

When: Saturday, Nov. 4, 7:30 p.m. ET

Where: Los Angeles Memorial Coliseum, Los Angeles, California

Cable TV: ABC

Streaming: ESPN app; FuboTV

How to watch: Catch the latest football action on Fubo

NCAAF odds Week 10: Washington Huskies at USC Trojans

The Huskies are favorites to stay undefeated in 2023 with a win over the Trojans, according to the BetMGM college football odds. Looking to wager? Check out the best mobile sports betting apps offering betting promos in 2023.

• Spread: Washington (-3)

• Moneyline: Washington (-160); USC (+130)

• Over/under: 77.5 points

Washington at USC injury report

• Huskies WR Giles Jackson (ankle) is questionable

• Huskies WR Jalen McMillan (leg) is questionable

• Trojans S Zion Branch (knee) is out for the season

Washington Huskies football schedule and results

• Week 1: Sat. 09/02: Washington 56-19 Boise State Final

• Week 2: Sat. 09/09: Washington 43-10 Tulsa Final

• Week 3: Sat 09/16: Washington 41-7 Michigan State Final

• Week 4: Sat. 09/23: Washington 59-32 Cal Final

• Week 5: Sat. 09/30: Washington 31-24 Arizona Final

• Week 6: Sat. 10/07: Bye

• Week 7: Sat. 10/14: Washington 36-33 Oregon Final

• Week 8: Sat. 10/21: Washington 15-7 Arizona State Final

• Week 9: Sat. 10/28: Washington 42-33 Stanford Final

• Week 10: Sat. 11/04: Washington at USC, 7:30 p.m., ET, ABC

• Week 11: Sat. 11/11: Washington vs. Utah, TBD

• Week 12: Sat. 11/18: Washington at Oregon State, TBD

• Week 13: Sat. 11/25: Washington vs. Washington State, TBD

USC Trojans football schedule and results

• Week 0: Sat. 08/26: USC 56-28 San Jose State Final

• Week 1: Sat. 09/02: USC 66-14 Nevada Final

• Week 2: Sat. 09/09: USC 56-10 Stanford Final

• Week 3: Sat. 09/16: Bye

• Week 4: Sat. 09/23: USC 42-28 Arizona State Final

• Week 5: Sat. 09/30: USC 48-41 Colorado Final

• Week 6: Sat. 10/07: USC 43-41 Arizona Final 3OT

• Week 7: Sat. 10/14: USC 20-48 Notre Dame Final

• Week 8: Sat. 10/21: USC 32-34 Utah Final

• Week 9: Sat. 10/28: USC 50-49 Cal Final

• Week 10: Sat. 11/04: USC vs. Washington, TBD

• Week 11: Sat. 11/11: USC at Oregon, TBD

• Week 12: Sat. 11/18: USC vs. UCLA, TBD

• Week 13: Sat. 11/25: Bye

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This article originally appeared on USA TODAY: USC-Washington schedule: Predictions, odds and how to watch epic game