USC schedule: odds, injury news, and how to watch Week 4 game vs. Arizona State

The No. 5 USC Trojans are back on the field this week and heading on the road to Arizona State to continue Pac-12 conference play. This matchup offers star quarterback Caleb Williams a good tune up ahead of the team's road showdown with Colorado Sept. 30.

This will be the 40th and last time USC and Arizona State face off as Pac-12 members. Next year, USC's heading to the Big 10 while Arizona State is set to join the Big 12.

This is the first road game of the year for the Trojans, who've hosted San Jose State, Nevada, and Stanford. All three were wins by a combined score of 178-52. Arizona State is 1-2 in head coach Kenny Dillingham's first season at the helm. Last week, the Sun Devils notched the first home shutout in 35 years with a 29-0 loss to Fresno State. With that recent loss, the Trojans are heavily favored to take their fourth straight win.

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How to watch No. 5 USC vs. Arizona State: TV and streaming

Arizona State will be hosting No. 5 USC with kickoff set for 10:30 p.m. ET. It will be broadcast live on Fox and streamed on the FoxSports App.

Notable football players and injury news:

• USC defensive lineman Tyrone Taleni is probable

• Arizona State quarterback Drew Pyne is probable

• Arizona State running back DeCarlos Brooks is questionable

• Arizona State tight end Jalin Conyers is questionable

• Arizona State quarterback Jaden Rashada is out

• Arizona State quarterback Trenton Bourguet is doubtful

• Arizona State defensive end Clayton Smith is doubtful

• Arizona State wide receiver Jordyn Tyson is out

• Arizona State offensive lineman Isaia Glass is questionable

• Arizona State running back George Hart III is questionable

Last year, Arizona State kept this game close through the first half before USC took over to win 42-25. Williams completed 27 of 37 passes for 348 yards and four total touchdowns (three passing, one rushing). With a different group of weapons this season, he'll look to replicate his success and maintain the top spot in the latest Heisman trophy odds.

On the other side, quarterback Drew Pyne makes his first start for Arizona State after transferring from Notre Dame. Pyne came in last week against Fresno State after injuries to starter Jaden Rashada and backup Trenton Bourguet. Pyne went 8-2 as a starter last year for the Irish and had 318 yards and three touchdowns in Notre Dame's 38-27 loss to the Trojans.

NCAA Odds Week 4: No. 5 USC vs. Arizona State lines, betting trends:

The Trojans are heavy favorites to defeat the Sun Devils, per multiple sportsbooks including BetMGM. Looking to wager? Check out the best mobile sports betting apps.

• Point Spread: USC -34.5

• Moneyline: USC -10000 / Arizona State +3000

• Over/Under: 62.5

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USC Trojans remaining schedule and results:

• Week 0: USC 56-28 San Jose State Final

• Week 1: USC 66-14 Nevada Final

• Week 2: USC 56-35 Colorado State Final

• Week 3: Bye

• Week 4: Sat. Sept. 23: USC-Arizona State, 10:30 p.m., ET, FOX

• Week 5: Sat. Sept. 30: USC-Colorado, 12:00 p.m., ET, FOX

• Week 6: Sat. Oct. 7: USC-Arizona, TBD

• Week 7: Sat. Oct. 14: USC-Notre Dame, time TBD, NBC/Peacock

• Week 8: Sat. Oct. 21: USC-Utah, TBD

• Week 9: Sat. Oct. 28: USC-California, TBD

• Week 10: Sat. Nov. 4: USC-Washington, TBD

• Week 11: Sat. Nov. 11: USC-Oregon, TBD

• Week 12: Sat. Nov. 18: USC-UCLA, TBD

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This article originally appeared on USA TODAY: Injury updates, betting info, and how to watch USC take on ASU