Serie A line-ups: Roma vs. Lazio
Claudio Ranieri tries to build Roma momentum with Paulo Dybala, Artem Dovbyk and Lorenzo Pellegrini, but high-flying Lazio look to Taty Castellanos and Mattia Zaccagni in the Derby della Capitale.
It kicks off at the Stadio Olimpico at 19.45 GMT.
There are a whopping 15 points separating the rivals in the Serie A table, as the Aquile are flying high in fourth place and also top of the Europa League table.
On the other hand, Roma are on their third coach of the campaign and old hand Ranieri has brought some stability thanks to a 5-0 victory over Parma and 1-1 draw away to Milan.
Bryan Cristante is still out with an ankle injury, while Zeki Celik has flu symptoms.
Dybala and centre-forward Dovbyk were never in doubt, but the big surprise from Ranieri is bringing under-fire captain Pellegrini back into the starting XI.
The 28-year-old has not started in Serie A since the 1-0 defeat to Napoli on November 24.
Lazio have quite a few issues to deal with, as Matias Vecino and Patric out of action, plus Pedro, Manuel Lazzari and Tijjani Noslin not at 100 per cent either.
Fresh from a hard-fought 1-1 draw with Serie A leaders Atalanta, the Biancocelesti had thousands of fans cheering them on in training yesterday.
Castellanos is backed by Zaccagni, Gustav Isaksen and Fisayo Dele-Bashiru.
There was a late change of referee due to injury for Marco Guida, so Luca Pairetto takes over the whistle.
Roma vs. Lazio line-ups
Roma: Svilar; Mancini, Hummels, N’Dicka; Saelemaekers, Konè, Paredes, Angelino; Dybala, Pellegrini; Dovbyk
Lazio: Provedel; Marusic, Gila, Romagnoli, Nuno Tavares; Guendouzi, Rovella, Dele-Bashiru; Isaksen, Castellanos, Zaccagni