Serie A line-ups: Lazio vs. Bologna
Lazio hope to continue their fine form despite missing Nuno Tavares, while Bologna have also won three on the bounce in Serie A.
It kicks off at the Stadio Olimpico in Rome at 19.45 GMT.
The Biancocelesti are in spectacular recent shape, sitting top of the Europa League table as the only side with a perfect record, while one point off Serie A leaders Napoli.
However, Nuno Tavares picked up a muscular problem on international duty with Portugal.
Boulaye Dia had a malaria scare while in Senegal, but Pedro and Taty Castellanos both start, despite reportedly not being fully fit.
Bologna have problems too ahead of their Champions League game with Lille, as Lukasz Skorupski is ruled out by flu symptoms and replaced by Nicola Ravaglia in goal.
He joins Nicolò Cambiaghi, Dan Ndoye, Michel Aebischer, Martin Erlic and Oussama El Azzouzi on the absentee list.
After a sluggish start under new coach Vincenzo Italiano, the Rossoblu won their last three Serie A games on the bounce and lost only once in the league this season.
A reminder that all players have red marks on their faces this weekend as part of a Serie A campaign on violence against women.
Lazio: Provedel; Lazzari, Gila, Romagnoli, Pellegrini; Guendouzi, Rovella, Vecino; Pedro, Castellanos, Zaccagni
Bologna: Ravaglia; De Silvestri, Beukema, Lucumì, Miranda; Pobega, Freuler; Orsolini, Odgaard, Karlsson; Castro
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