San Francisco 49ers at Philadelphia Eagles: Predictions, picks and odds for NFL Week 13 game

The NFC Championship game rematch is here.

The San Francisco 49ers (8-3) return to Lincoln Financial Field to take on the Philadelphia Eagles (10-1) in what could be a preview of another playoff matchup.

All things are clicking for the 49ers as they've won three straight games, the latest win coming in a Thanksgiving victory over the Seattle Seahawks. Christian McCaffrey got into the end zone once again while the defense made life tough for Geno Smith and the rest of the Seattle offense.

Philadelphia is coming off winning perhaps the game of the year in an overtime thriller against the Buffalo Bills. Despite the dreadful first-half performance, the Eagles showed why they have the best record in the NFL and can get another statement win against a team that wants revenge for last season.

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San Francisco 49ers defensive end Nick Bosa (97) battles with Philadelphia Eagles offensive tackle Lane Johnson (65) during the second quarter in the NFC Championship game at Lincoln Financial Field.
San Francisco 49ers defensive end Nick Bosa (97) battles with Philadelphia Eagles offensive tackle Lane Johnson (65) during the second quarter in the NFC Championship game at Lincoln Financial Field.

Eagles vs. 49ers odds, moneyline, over/under

The 49ers are favorites to defeat the Eagles, according to the BetMGM NFL odds. Looking to wager? Check out the best mobile sports betting apps offering NFL betting promos in 2023, including the new ESPN BET app.

  • Spread: 49ers (-3)

  • Moneyline: 49ers (-155); Eagles (+130)

  • Over/under: 48

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NFL Week 13 odds, predictions and picks

Cowboys vs. Seahawks | Patriots vs. Chargers | Saints vs. Lions | Jets vs. Falcons | Steelers vs. Cardinals | Titans vs. Colts | Commanders vs. Dolphins | Texans vs. Broncos | Buccaneers vs. Panthers | Eagles vs. 49ers | Rams vs. Browns | Packers vs. Chiefs | Jaguars vs. Bengals

Lorenzo Reyes: Eagles 25, 49ers 20

The 49ers can present a couple of problems for the Eagles; San Francisco’s ferocious pass rush could generate pressure that disrupts Jalen Hurts and the Philly offense. But the Eagles have met every challenge they’ve faced and the key to this game will be to keep third- and fourth-down distances manageable; Philadelphia is first in the NFL in fourth-down conversion rate, moving the chains an astonishing 76.5% of the time, but also rank third in third-down efficiency (47.3%). The Niners' defense on third downs is in the bottom third of the league. I have a hard time going against the Eagles at home, especially when they’re getting a field goal.

Tyler Dragon: 49ers 25, Eagles 24

The game of the week. This NFC title game rematch is worth the hype. The 49ers and Eagles are once again the two best teams in the conference. The 49ers don’t tend to lose games when Deebo Samuel, Trent Williams, Christian McCaffrey and Brock Purdy are all on the field together and healthy. San Francisco has revenge on its mind after losing in the NFC Championship game last season.

Safid Deen: Eagles 27, 49ers 20

The game of the week between the two best teams in the NFL. Both sides are stacked, but I’m giving the edge to the Eagles because of the quarterback position. Give me Jalen Hurts over Brock Purdy every day of the week.

Victoria Hernandez: Eagles 27, 49ers 26

This is probably the game of the week and a possible preview of the NFC championship as two of the grittiest teams in the conference face off. They might not be the most high-powered team in the league, but the Eagles continue to churn out win after win with sheer determination. They’re facing a stiff defense and a well-balanced offense in the 49ers, but being at home and sticking to their unique brand of football should squeak out another victory.

Jordan Mendoza: Eagles 33, 49ers 31

This game is going to be intense. San Francisco will want to prove that when they have a healthy quarterback, they can beat anybody, even the Eagles. Coming off a gritty win, Philadelphia has shown they can win even in bad performances. Even with the momentum San Francisco has, it's tough to win inside the Linc. It's close, but the Eagles get another last-second victory in another thriller.

You can view the full list of USA TODAY's NFL expert predictions here.

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This article originally appeared on USA TODAY: San Francisco 49ers at Philadelphia Eagles: Game predictions, picks, odds