Marco Rose now has two wins and two defeats from four games in charge of the German club and will be hoping to kick-start their continental campaign.
Two defeats to open their group efforts leave Leipzig fighting to get back on track, and Rose’s side can ill-afford a defeat to Celtic.
A single point earned against Shakhtar Donetsk in Warsaw means Ange Postecoglou sit above their opponents in what looks to be a competitive battle for the second qualification place in a group likely to be topped by Real Madrid.
Here’s everything you need to know ahead of the fixture.
When and where is it?
RB Leipzig vs Celtic is due to kick off at 5.45pm BST on Wednesday 5 October at the Red Bull Arena in Leipzig, Germany.
How can I watch it?
Viewers in the United Kingdom can watch the match live on BT Sport 4, with coverage from 5pm BST. Subscribers can stream the game via the BT Sport app or online player.
RB Leipzig XI: Gulacsi, Simakan, Orban, Gvardiol, Raum, Schlager, Kampl, Szoboszlai, Nkunku, Werner, Silva.
Celtic XI: Hart; Juranovic, Jenz, Welsh, Taylor; McGregor, Hatate, O’Riley; Jota, Furuhashi, Maeda
RB Leipzig win 4/7
Celtic win 5/1
RB Leipzig get their European campaign up and running with a home win. RB Leipzig 2-1 Celtic