Wout Weghorst, who has only scored twice in his loan spell and who has not found the net in his last 15 games, is the other option available to manager Erik ten Hag.
Martial has been Ten Hag’s first-choice striker this season but has only started 17 of their 61 matches in all competitions and has only struck two goals in his last 12 appearances.
However, he did score twice against City as a substitute in United’s 6-3 defeat at the Etihad Stadium in October.
Concerns about Martial’s fitness are a reason why Ten Hag’s major objective in the summer transfer market is to sign a centre-forward.
United are also waiting to see if winger Antony will recover from an ankle injury in time, with Ten Hag saying the Brazilian will "probably" be fit.