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Indianapolis Colts vs. New England Patriots: Predictions, picks and odds for NFL Week 10 game

The NFL is headed back to Germany, although this time it won't be between two potential playoff teams when the Indianapolis Colts (4-5) and New England Patriots (2-7) will meet in Frankfurt.

Things were starting to go downhill, but Indianapolis was able to snap a three-game losing skid in a win over the Carolina Panthers. The defense had been shaky during the losing streak but came up big thanks to Kenny Moore II making the difference with two pick-6s. If the defense can continue to play like it did against the Panthers, the Colts could make a playoff push.

The Patriots' downward spiral continued last week as a late-game interception from Mac Jones cost New England a chance at defeating the Washington Commanders. The team is now off to its worst start since Bill Belichick’s first season in 2000, and questions continue to linger about what is the future of the team as they are positioned for a top-10 pick in next year's draft.

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New England Patriots running back Rhamondre Stevenson (38) runs with the ball past Indianapolis Colts defensive tackle Grover Stewart (90) during the second half at Gillette Stadium.
New England Patriots running back Rhamondre Stevenson (38) runs with the ball past Indianapolis Colts defensive tackle Grover Stewart (90) during the second half at Gillette Stadium.

Patriots vs. Colts odds, moneyline, over/under

The Colts are favorites to defeat the Patriots, according to the BetMGM NFL odds. Looking to wager? Check out the best mobile sports betting apps offering NFL betting promos in 2023, including the new ESPN BET app.

  • Spread: Colts (-1.5)

  • Moneyline: Colts (-130); Patriots (+110)

  • Over/under: 43

Not interested in this game? Our guide to the NFL betting odds, picks and spreads has you covered with Thursday Night Football odds, Sunday Night Football odds and/or Monday Night Football odds.

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NFL Week 10 odds, predictions and picks

Bears vs. Panthers | Patriots vs. Colts | Ravens vs. Browns | Bengals vs. Texans | Jaguars vs. 49ers | Vikings vs. Saints | Steelers vs. Packers | Buccaneers vs. Titans | Cardinals vs. Falcons | Chargers vs. Lions | Cowboys vs. Giants | Seahawks vs. Commanders | Raiders vs. Jets | Bills vs. Broncos

Lorenzo Reyes: Colts 23, Patriots 15

With this line at a near pick-‘em, I think the Colts are a safe play. The Patriots turn the ball over far too often and the Colts have been an aggressive defense in forcing takeaways, generating six over their last three games. New England’s roster, simply put, is deficient in far too many areas.

Tyler Dragon: Colts 24, Panthers 20

The Patriots have the 27th ranked offense in the NFL and their 15 points per game average is the worst in the AFC. If the Colts hand the rock off to running back Jonathan Taylor and take care of the football, they should be victorious.

Safid Deen: Colts 26, Patriots 18

The Colts finally broke through with a win last week against the Panthers, and their momentum should carry over in Germany, while the Patriots are trekking to nowhere this season because of an abysmal offense.

Victoria Hernandez: Patriots 23, Colts 19

Both teams have basically the same travel schedule for this overseas game, so there’s no clear advantage one way or another there. Bill Belichick is undefeated in international games (although he did have Tom Brady), and the Patriots also have international marketing rights in Germany, which might help create somewhat of a home-game atmosphere.

Jordan Mendoza: Colts 23, Patriots 19

The international games this season have been relatively low-scoring, with the winning team scoring no more than 25 points. The Patriots have had a tough time scoring, and they have an opportunity to get better against a shaky Indianapolis defense. But the Colts defense has another strong game as they get to .500.

You can view the full list of USA TODAY's NFL expert predictions here.

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This article originally appeared on USA TODAY: Indianapolis Colts vs. New England Patriots: Predictions, picks, odds