Europa League line-ups: Roma vs. Eintracht Frankfurt
Roma risk elimination from the Europa League as they host Eintracht Frankfurt with Paulo Dybala, Lorenzo Pellegrini and Artem Dovbyk.
It kicks off at the Stadio Olimpico at 20.00 GMT.
The Giallorossi find themselves in 21st place and run the genuine risk of going out of the competition at the first phase.
Bryan Cristante is still out of action, but Pellegrini and Dybala return to support centre-forward Dovbyk.
Mats Hummels is also back after he was rested, but new buy Devyne Rensch is ineligible.
They face their toughest test yet, because Eintracht Frankfurt are second in the Europa League table behind Lazio after five victories, a draw and one defeat at Lyon.
The team is weaker than it was, having sold top scorer Omar Marmoush to Manchester City, while Elye Wahi is cup-tied after his transfer from Olympique Marseille.
Junior Dina Ebimbe and Nathanial Brown are also on the treatment table.
Hugo Ekitiké leads the attack with 16 goals in 28 competitive games this season, while Rasmus Kristensen is a former Roma player and Arthur Theate remembered for his time at Bologna.
Roma: Svilar; Mancini, Hummels, N’Dicka; Saelemaekers, Paredes, Kone, Angelino; Dybala, Pellegrini; Dovbyk
Eintracht Frankfurt: Trapp; Tuta, Koch, Theate; R Kristensen, Shkiri, Larsson, Knauff; Bahoya, Chaibi; Ekitiké
Ref: Obrenovic (SVN)