Last season, the Bundesliga club triumphed in the Europa League final on penalties to earn their spot in this competition - they are currently sixth in their domestic table, with Spurs third in their own.
Harry Kane and Co will be hoping to find winning ways again after also losing late on to Sporting CP in their last European outing.
Here’s everything you need to know ahead of the game.
When is Eintracht Frankfurt vs Tottenham?
The match kicks off at 8pm BST on Tuesday 4 October.
Where can I watch the game?
Spurs’ trip to Germany will be broadcast in the UK live on BT Sport 3. Subscribers can stream the game via the BT Sport app and desktop website.
EIN - Trapp, Tuta, Hasebe, Ndicka, Knauff, Rode, Sow, Jakic, Lindstrom, Kamada, Muani
TOT - Lloris, Romero, Dier, Lenglet, Royal, Hojbjerg, Bentancur, Perisic, Richarlison, Kane, Son
Spurs to have enough to come away with a very valuable win on the road. Eintracht 1-2 Tottenham.