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Cardinals vs. Eagles preview: Predictions, odds, and how to watch Sunday's game

Kyler Murray #1 of the Arizona Cardinals walks off the field after the game against the Chicago Bears at Soldier Field on Dec. 24, 2023, in Chicago, Illinois.
Kyler Murray #1 of the Arizona Cardinals walks off the field after the game against the Chicago Bears at Soldier Field on Dec. 24, 2023, in Chicago, Illinois.

The Philadelphia Eagles (11-4) host the Arizona Cardinals (3-12) at Lincoln Financial Field as part of the early slate of NFL games in Week 17.

The Cardinals come in to the second-to-last week of the regular season on a two-game losing streak. Last week's 27-16 loss to the Chicago Bears was the worst game of the season for the Cardinals' run defense. Chicago gained 250 yards on the ground and put the game away with a field goal in the final minute. Arizona's offense struggled as well one week after a season-high 436 yards against the San Francisco 49ers. Quarterback Kyler Murray went 24-of-38 passing with 230 yards and two touchdowns.

Philadelphia head into Week 17 a week after ending a three-game losing streak with a 33-25 win over the New York Giants on Christmas. Quarterback Jalen Hurts also went 24-of-38 through the air with 301 yards and two total touchdowns (one passing, one rushing). Unfortunately his one interception was returned for a touchdown late in the third quarter which kept the Giants in the game through the final frame.

This game is Arizona head coach Jonathan Gannon's first game against the Eagles since leaving Philadelphia's defensive coordinator position to take the Cardinals job. In his absence, the Eagles' defense has dropped from eighth to 25th in the league in points allowed.

How to watch Arizona Cardinals at Philadelphia Eagles: TV channel and streaming info

The Arizona Cardinals kick off against the Philadelphia Eagles on Sunday, Dec. 31, at 1:00 p.m., ET, on FOX. The game can also be streamed on NFL+ and the Fox Sports app.

Week 17: Arizona Cardinals at Philadelphia Eagles Predictions

Arizona Republic: Eagles 30, Cardinals 17

Jeremy Cluff writes: "Jonathan Gannon makes his return to Philadelphia, now as the Cardinals head coach. It won't go well for Arizona."

Pickswise: Arizona +11

Caleb Wilfinger says: "The Eagles have been sloppy, and last week Hurts’ interception-turned-TD and more egregious mistakes kept a lowly Giants’ team in the contest until the end... The Cards have also had success against the NFC East this season. They beat Dallas straight up and nearly beat the Giants and Commanders. Over a 10-point spread, we see value on Arizona."

KOLD: Eagles 30, Cardinals 18

Staff writes: "Philadelphia has won six games against the spread this season, while failing to cover or pushing nine times."

Clutchpoints: Eagles -10.5

Chris Spiering says: "The Cardinals are coming off an 11-point loss to the Chicago Bears. The Eagles are capable of really putting it on the Cardinals and I expect them to cover this spread. Buying a point to -9.5 might be a safer call but either way, the Eagles are the better team by far and will cruise with a win at home."

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Week 17: Arizona Cardinals at Philadelphia Eagles odds, betting lines

The Philadelphia Eagles are heavy favorites to defeat the Arizona Cardinals, according to the BetMGM NFL odds.

Looking to wager? Check out the best mobile sports betting apps offering NFL betting promos in 2023.

  • Spread: Eagles (-12.5)

  • Moneyline: Eagles (-750); Cardinals (+525)

  • Over/under: 48

How to watch: Catch football action with a Fubo subscription

Week 17: Arizona Cardinals at Philadelphia Eagles injury news

Arizona Cardinals:

Player

Position

Injury

Status

Marquise Brown

WR

Heel

Out

Zaven Collins

LB

Ankle

Questionable for Week 17

Jonathan Ledbetter

DE

Knee

Out

Kyler Murray

QB

Illness

Questionable for Week 17

Andre Chachere

S

Shoulder

Questionable for Week 17

Victor Dimukeje

LB

Foot

Questionable for Week 17

Leki Fotu

DT

Hand

Out

Owen Pappoe

LB

Ankle

Questionable for Week 17

Bobby Price

DB

Quad

Questionable for Week 17

Kevin Strong

DT

Knee

Questionable for Week 17

Garrett Williams

CB

Knee

Questionable for Week 17

Philadelphia Eagles:

Player

Position

Injury

Status

Darius Slay

CB

Knee

Out

Zach Cunningham

LB

Knee

Doubtful for Week 17

Nicholas Morrow

LB

Abdomen

Questionable for Week 17

Landon Dickerson

OG

Thumb

Questionable for Week 17

Avonte Maddox

CB

Pectoral

Questionable for Week 17

Albert Okwuegbunam

TE

Hamstring

Out

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This article originally appeared on USA TODAY: Cardinals vs. Eagles predictions, odds, injury news for Sunday's game