While it was always unlikely Liverpool would be able to catch the Red Devils on the final day, the three points make it mathematically impossible.
“We know it means a lot [to the fans],” Fernandes told Sky Sports.
“For us it’s about getting our goals. We know we’d be happy also for Liverpool to not be there but for us it’s about getting the best for ourselves.”
It is the first time Jurgen Klopp’s side have played in Europe’s secondary club competition since his first few months at the club in the 2015/16.
United could yet spoil another rival’s season when they meet Manchester City in the FA Cup final next month as Pep Guardiola’s side chase what could be a treble.