What the team doesn't know is whether the receiver will be able to play in the NFC championship game when the 49ers host the Detroit Lions.
ESPN's Adam Schefter reported that Samuel is considered "50-50" for Sunday's contest.
The 49ers are particularly wary about the health of Samuel's shoulder because he already sustained a hairline fracture in his shoulder in Week 6 of the regular season. San Francisco then proceeded to lose its next two games without him in the lineup.
This is the third consecutive NFC title bout for San Francisco.