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2024 March Madness: What is the spread for every Sweet 16 game this weekend?

Arizona Wildcats guard Caleb Love (2) shoots the ball during the first half against Arizona Wildcats in the first round of the 2024 NCAA Tournament at Vivint Smart Home Arena-Delta Center.
Arizona Wildcats guard Caleb Love (2) shoots the ball during the first half against Arizona Wildcats in the first round of the 2024 NCAA Tournament at Vivint Smart Home Arena-Delta Center.

We've now had three days to ponder the Round of 32 and decide how we feel about the teams left standing. March Madness returns tonight and anything can happen!

With four games set to tip-off tonight, all of which including a No. 1 or No. 2 seed, the Sweet 16 could be absolutely thrilling. A ticket to the Elite Eight is on the line, but for those of us looking to spice things up by throwing some money on certain teams, there's something on the line for us as well. So, get your snacks, brackets, and monitors ready. The madness is back and it starts at 7:09 p.m. ET!

Here are the odds, lines, and spreads for every Sweet 16 game. All odds via BetMGM.

2024 NCAA Tournament picks: Predictions for Thursday's Sweet 16 games

Sweet 16: Betting odds, lines and spreads

Thursday, March 28:

No. 6 Clemson vs. No. 2 Arizona - 7:09 p.m. ET

The Wildcats are favorites to defeat the Tigers, according to the BetMGM NCAA odds. Looking to wager? Check out the best mobile sports betting apps offering NCAA betting promos in 2023.

  • Spread: Arizona (-7.5)

  • Moneyline: Arizona (-300); Clemson (+250)

  • Over/under: 152.5

No. 5 San Diego State vs. No. 1 UConn - 7:39 p.m. ET

The Huskies are favorites to defeat the Aztecs, according to the BetMGM NCAA odds. Looking to wager? Check out the best mobile sports betting apps offering NCAA betting promos in 2023.

  • Spread: UConn (-11.5)

  • Moneyline: UConn (-800); San Diego State (+550)

  • Over/under: 136.5

No. 4 Alabama vs. No. 1 North Carolina - 9:39 p.m. ET

The Tar Heels are slight favorites to defeat the Crimson Tide, according to the BetMGM NFL odds. Looking to wager? Check out the best mobile sports betting apps offering NFL betting promos in 2023.

  • Spread: North Carolina (-4.5)

  • Moneyline: North Carolina (-200); Alabama (+165)

  • Over/under: 174.5

No. 3 Illinois vs. No. 2 Iowa State - 10:09 p.m. ET

The Cyclones are slight favorites to defeat the Illini, according to the BetMGM NCAA odds. Looking to wager? Check out the best mobile sports betting apps offering NCAA betting promos in 2023.

  • Spread: Iowa State (-1.5)

  • Moneyline: Iowa State (-120); Illinois (+100)

  • Over/under: 147.5

Friday, March 29:

No. 11 NC State vs. No. 2 Marquette - 7:09 p.m. ET

The Golden Eagles are slight favorites to defeat the Wolfpack, according to the BetMGM NCAA odds. Looking to wager? Check out the best mobile sports betting apps offering NCAA betting promos in 2023.

  • Spread: Marquette (-6.5)

  • Moneyline: Marquette (-300); NC State (+230)

  • Over/under: 151.5

No. 5 Gonzaga vs. No. 1 Purdue - 7:39 p.m. ET

The Boilermakers are favorites to defeat the Bulldogs, according to the BetMGM NCAA odds. Looking to wager? Check out the best mobile sports betting apps offering NCAA betting promos in 2023.

  • Spread: Purdue (-5.5)

  • Moneyline: Purdue (-225); Gonzaga (+185)

  • Over/under: 154.5

No. 4 Duke vs. No. 1 Houston - 9:39 p.m. ET

The Cougars are slight favorites to defeat the Blue Devils, according to the BetMGM NCAA odds. Looking to wager? Check out the best mobile sports betting apps offering NCAA betting promos in 2023.

  • Spread: Houston (-3.5)

  • Moneyline: Houston (-190); Duke (+155)

  • Over/under: 134.5

No. 3 Creighton vs. No. 2 Tennessee - 10:09 p.m. ET

The Volunteers are slight favorites to defeat the Bluejays, according to the BetMGM NCAA odds. Looking to wager? Check out the best mobile sports betting apps offering NCAA betting promos in 2023.

  • Spread: Tennessee (-3.5)

  • Moneyline: Tennessee (-155); Creighton (+130)

  • Over/under: 144.5

March Madness games today: Everything to know about NCAA Tournament's Sweet 16 schedule

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This article originally appeared on USA TODAY: March Madness 2024: odds, lines, spreads for every Sweet 16 game