Rob Gronkowski, Mario Manningham headline Patriots, 49ers inactive lists

Despite returning to practice this week, New England Patriots tight end Rob Gronkowski is inactive for Sunday night's game against the San Francisco 49ers. Gronkowski, who was listed as "questionable" on Friday, will miss a fourth straight game since breaking his forearm late in a win over the Indianapolis Colts on Nov. 18.

For the 49ers, wide receiver Mario Manningham will miss a second consecutive game due to a shoulder injury. Initially listed as "doubtful", Manningham was downgraded to "out" on Saturday.

San Francisco: RB Jewel Hampton, WR Mario Manningham, G Joe Looney, NT Ian Williams, LB Tavares Gooden, S Trenton Robinson

New England: TE Rob Gronkowski, OT Marcus Zusevics, DT Ron Brace, DE Jake Bequette, LB Tracy White, S Derrick Martin

Both the Patriots and 49ers have 52 players on their active roster and were required to submit a list of six inactive players.