| | S | Activated (The Detroit Lions elevated SAF Brandon Joseph to the active roster. ) |
| | T | Activated (The Detroit Lions elevated T Dan Skipper to the active roster. ) |
| | DL | Released (The Detroit Lions released DL Chris Smith.) |
| | LB | Pract. squad add (The Detroit Lions signed LB Mitchell Agude to the practice squad.) |
| | RB | Pract. squad add (The Detroit Lions signed RB Devine Ozigbo to the practice squad.) |
| | T | Pract. squad add (The Detroit Lions signed OL Dan Skipper to the practice squad.) |
| | CB | Pract. squad add (The Detroit Lions signed DB Darius Phillips to the practice squad.) |
| | LB | Placed on Injured Reserve (The Detroit Lions placed DE James Houston on Injured Reserve.) |
| | DB | Placed on Injured Reserve (The Detroit Lions placed CB C.J. Gardner-Johnson on Injured Reserve.) |
| | G | Activated (The Detroit Lions signed OL Kayode Awosika to the active roster.) |
| | RB | Activated (The Detroit Lions signed RB Zonovan Knight to the active roster.) |
| | G | Pract. squad add (The Detroit Lions assigned OL Kayode Awosika to the practice squad.) |
| | CB | Placed on Injured Reserve (The Detroit Lions placed CB Khalil Dorsey on injured reserve. ) |
| | DL | Placed on Injured Reserve (The Detroit Lions placed DL Josh Paschal on injured reserve.) |
| | G | Activated (The Detroit Lions elevated G Kayode Awosika to the active roster. ) |
| | CB | Signed (The Detroit Lions signed CB Chase Lucas to the active roster. ) |
| | TE | Pract. squad add (The Detroit Lions signed TE Darrell Daniels to the practice squad.) |
| | RB | Pract. squad add (The Detroit Lions signed RB Zonovan Knight to the practice squad.) |
| | QB | Pract. squad add (The Detroit Lions signed QB Davis Blough to the practice squad.) |
| | OL | Pract. squad add (The Detroit Lions signed T Michael Niese to the practice squad.) |
| | DL | Pract. squad add (The Detroit Lions signed DE Raymond Johnson to the practice squad.) |
| | LB | Placed on Injured Reserve (The Detroit Lions placed LB Julian Okwara on the IR.) |
| | RB | Signed (The Detroit Lions signed RB Craig Reynolds.) |
| | DT | Pract. squad add (The Detroit Lions signed DT Quinton Bohanna to the practice squad.) |
| | WR | Pract. squad add (The Detroit Lions signed WR Daurice Fountain to the practice squad.) |
| | LB | Pract. squad add (The Detroit Lions signed LB Trevor Nowaske to the practice squad.) |
| | K | Pract. squad add (The Detroit Lions signed K Michael Badgley to the practice squad.) |
| | OL | Pract. squad add (The Detroit Lions signed T Connor Galvin to the practice squad.) |
| | DL | Pract. squad add (The Detroit Lions signed DL Chris Smith to the practice squad.) |
| | CB | Pract. squad add (The Detroit Lions signed CB Chase Lucas to the practice squad.) |
| | S | Pract. squad add (The Detroit Lions signed S Brandon Joseph to the practice squad.) |
| | WR | Pract. squad add (The Detroit Lions signed WR Dylan Drummond to the practice squad.) |
| | WR | Pract. squad add (The Detroit Lions signed WR Maurice Alexander to the practice squad.) |
| | T | Pract. squad add (The Detroit Lions signed T Max Pircher to the practice squad.) |
| | G | Pract. squad add (The Detroit Lions signed G Kayode Awosika to the practice squad.) |
| | CB | Waived (The Detroit Lions waived CB Starling Thomas.) |
| | T | Waived (The Detroit Lions waived T Max Pircher.) |
| | WR | Waived Injury (The Detroit Lions waived WR Chase Cota due to injury.) |
| | RB | Released (The Detroit Lions released RB Craig Reynolds.) |
| | C | Waived (The Detroit Lions waived C Brad Cecil.) |
| | DT | Waived (The Detroit Lions waived DL Cory Durden.) |
| | S | Waived (The Detroit Lions waived S Brady Breeze.) |
| | K | Waived (The Detroit Lions waived K Parker Romo.) |
| | DL | Waived (The Detroit Lions waived DL Chris Smith.) |
| | QB | Placed on Injured Reserve (The Detroit Lions placed QB Nate Sudfeld on Injured Reserve.) |
| | TE | Released (The Detroit Lions released TE Darrell Daniels.) |
| | LB | Waived (The Detroit Lions waived LB Trevor Nowaske.) |
| | WR | Waived (The Detroit Lions waived WR Maurice Alexander.) |
| | RB | Waived Injury (The Detroit Lions waived RB Jermar Jefferson due to injury.) |
| | RB | Released (The Detroit Lions released RB Benny Snell.) |
| | S | Waived (The Detroit Lions waived S Brandon Joseph.) |
| | CB | Waived (The Detroit Lions waived CB Chase Lucas. ) |
| | WR | Waived (The Detroit Lions waived WR Dylan Drummond.) |
| | G | Waived (The Detroit Lions waived OL Kayode Awosika.) |
| | OL | Waived (The Detroit Lions waived OL Ryan Swoboda.) |
| | OL | Released (The Detroit Lions released OL Connor Galvin.) |
| | QB | Waived (The Detroit Lions waived QB Adrian Martinez.) |
| | WR | Waived (The Detroit Lions waived WR Trinity Benson.) |
| | OL | Released (The Detroit Lions released OL Bobby Hart.) |
| | RB | Released (The Detroit Lions released RB Devine Ozigbo.) |
| | WR | Released (The Detroit Lions released WR Jason Moore.) |
| | CB | Waived (The Detroit Lions waived DB Colby RIchardson.) |
| | T | Waived (The Detroit Lions waived OL Darrin Paulo.) |
| | S | Waived (The Detroit Lions waived DB Scott Nelson.) |
| | C | Waived (The Detroit Lions waived OL Alex Mollette.) |
| | T | Waived (The Detroit Lions waived OL Obinna Eze.) |
| | G | Released (The Detroit Lions released OL German Ifedi.) |
| | WR | Waived (The Detroit Lions waived WR Avery Davis.) |
| | TE | Released (The Detroit Lions released TE Daniel Helm. ) |
| | RB | Waived Injury (The Detroit Lions waived RB Mohamed Ibrahim with an injury settlement. ) |
| | DL | Released (The Detroit Lions released DL Christian Covington. ) |
| | WR | Waived Injury (The Detroit Lions waived WR Denzel Mims due to injury.) |
| | DB | Waived Injury (The Detroit Lions waived DB Saivion Smith due to injury.) |
| | RB | Placed on Injured Reserve (The Detroit Lions placed RB Mohamed Ibrahim on injured reserve, after being waived due to injury. ) |
| | S | Signed (The Detroit Lions signed DB Scott Nelson.) |
| | RB | Waived Injury (The Detroit Lions waived RB Mohamed Ibrahim.) |
| | WR | Placed on Injured Reserve (The Detroit Lions placed WR Denzel Mims on injured reserve after being waived due to injury. ) |
| | WR | Waived Injury (The Detroit Lions waived WR Denzel Mims due to injury.) |
| | WR | Signed (The Detroit Lions signed WR Jason Moore.) |
| | WR | Waived (The Detroit Lions waived WR Trey Quinn.) |
| | WR | Placed on Injured Reserve (The Detroit Lions placed WR Trey Quinn on injured reserve.) |
| | WR | Signed (The Detroit Lions signed WR Avery Davis.) |
| | WR | Waived (The Detroit Lions waived WR Trey Quinn.) |
| | C | Signed (The Detroit Lions signed OL Alex Mollette.) |
| | CB | Signed (The Detroit Lions signed DB Colby Richardson.) |
| | G | Waived Injury (The Detroit Lions waived OL Ross Pierschbacher.) |
| | OL | Waived (The Detroit Lions waived OL Logan Stenberg.) |
| | RB | Signed (The Detroit Lions signed RB Benny Snell.) |
| | RB | Retired (RB Justin Jackson retired from the NFL.) |
| | WR | Waived (The Detroit Lions waived WR Avery Davis.) |
| | RB | Signed (The Detroit Lions signed RB Devine Ozigbo.) |
| | QB | Signed (The Detroit Lions signed QB Teddy Bridgewater.) |
| | OL | Signed (The Detroit Lions signed T Bobby Hart.) |
| | LS | Released (The Detroit Lions released LS Jake McQuaide.) |
| | WR | Waived Injury (The Detroit Lions waived WR Tom Kennedy due to injury.) |
| | DL | Waived (The Detroit Lions waived DL Zach Morton.) |
| | CB | Waived Injury (The Detroit Lions waived CB Jarren Williams due to injury.) |
| | CB | Signed (The Detroit Lions signed DB Tae Hayes.) |
| | TE | Signed (The Detroit Lions signed TE Daniel Helm.) |
| | TE | Waived (The Detroit Lions waived TE Derrick Deese Jr.) |
| | TE | Signed (The Detroit Lions signed TE Darrell Daniels.) |
| | TE | Placed on Injured Reserve (The Detroit Lions placed TE Shane Zylstra on the IR after being waived due to injury.) |
| | TE | Waived Injury (The Detroit Lions waived TE Shane Zylstra with an injury designation.) |
| | WR | Activated (The Detroit Lions activated WR Marvin Jones Jr.) |
| | WR | Placed on Injured Reserve (The Detroit Lions placed WR Tom Kennedy on the IR after being waived.) |
| | WR | Signed (The Detroit Lions signed WR Trey Quinn.) |
| | WR | Waived (The Detroit Lions waived WR Tom Kennedy.) |
| | CB | Placed on PUPL (The Detroit Lions placed DB Emmanuel Moseley on the PUP list.) |
| | WR | Reserve/non football injury (The Detroit Lions placed WR Marvin Jones Jr. on the NFI list.) |
| | DL | Activated (The Detroit Lions activated DL Zach Morton from Non Football injury list.) |
| | TE | Activated (The Detroit Lions activated TE Derrick Deese from Non Football injury list.) |
| | TE | Reserve/non football injury (The Detroit Lions placed TE Derrick Deese Jr. on the Non Football injury list.) |
| | K | Released (The Detroit Lions released K Michael Badgley.) |
| | WR | Traded (The New York Jets traded WR Denzel Mims to the Detroit Lions.) From |
| | DL | Reserve/non football injury (The Detroit Lions placed DL Zach Morton on the Non Football injury list.) |
| | QB | Reserve/non football injury (The Detroit Lions placed QB Hendon Hooker on the Non Football injury list.) |
| | K | Traded (The Jacksonville Jaguars traded K Riley Patterson to the Detroit Lions.) From |
| | WR | Released (The Detroit Lions released WR Keytaon Thompson.) |
| | LB | Waived (The Detroit Lions waived LB Isaac Darkangelo.) |
| | G | Signed (The Detroit Lions signed OL Germain Ifedi.) |
| | LB | Signed (The Detroit Lions signed LB Jack Campbell.) |
| | T | Signed (The Detroit Lions signed OL Max Pircher.) |
| | RB | Signed (The Detroit Lions signed RB Greg Bell.) |
| | K | Signed (The Detroit Lions signed K John Parker Romo. ) |
| | WR | Signed (The Detroit Lions signed WR Dylan Drummond.) |
| | DL | Signed (The Detroit Lions signed DL Christian Covington.) |
| | DL | Waived (The Detroit Lions waived DL Demetrius Taylor.) |
| | CB | Waived (The Detroit Lions waived DB Mac McCain III.) |
| | WR | Waived (The Detroit Lions waived WR Stanley Berryhill.) |
| | DT | Signed (The Detroit Lions signed undrafted free agent DT Cory Durden. ) |
| | DL | Signed (The Detroit Lions signed undrafted free agent DL Zach Morton. ) |
| | CB | Signed (The Detroit Lions signed undrafted free agent CB Starling Thomas V. ) |
| | WR | Signed (The Detroit Lions signed undrafted free agent WR Keytaon Thompson. ) |
| | LB | Signed (The Detroit Lions signed undrafted free agent LB Trevor Nowaske. ) |
| | WR | Signed (The Detroit Lions signed undrafted free agent WR Chase Cota. ) |
| | DL | Signed (The Detroit Lions signed undrafted free agent DL Chris Smith. ) |
| | C | Signed (The Detroit Lions signed undrafted free agent OL Brad Cecil. ) |
| | RB | Signed (The Detroit Lions signed undrafted free agent RB Mohamed Ibrahim. ) |
| | S | Signed (The Detroit Lions signed undrafted free agent FS Brandon Joseph. ) |
| | OL | Signed (The Detroit Lions signed undrafted free agent OL Ryan Swoboda. ) |
| | TE | Other Transaction (The Detroit Lions acquired TE Alex Murtagh through the International Player Pathway Program.) |
| | RB | Traded (The Detroit Lions traded RB D'Andre Swift to the Philadelphia Eagles.) To |
| | S | Released (The Detroit Lions released S C.J. Moore.) |
| | WR | Released (The Detroit Lions released WR Quintez Cephus.) |
| | DB | Re-signed (The Detroit Lions re-signed DB Saivion Smith.) |
| | TE | Re-signed (The Detroit Lions re-signed TE Shane Zylstra.) |
| | TE | Re-signed (The Detroit Lions re-signed TE Brock Wright.) |
| | CB | Traded (The Detroit Lions traded DB Jeff Okudah to the Atlanta Falcons.) To |
| | WR | Signed (The Detroit Lions signed WR Marvin Jones Jr.) |
| | QB | Re-signed (The Detroit Lions re-signed QB Nate Sudfeld.) |
| | LB | Signed (The Detroit Lions signed LB Jalen Reeves-Maybin.) |
| | OL | Signed (The Detroit Lions signed OL Graham Glasgow.) |
| | CB | Signed (The Detroit Lions signed DB Emmanuel Moseley.) |
| | DL | Re-signed (The Detroit Lions re-signed DL John Cominsky.) |
| | CB | Re-signed (The Detroit Lions re-signed DB Will Harris.) |
| | WR | Declared Free Agent (WR DJ Chark declared free agency.) |
| | CB | Signed (The Detroit Lions signed CB Cameron Sutton.) |
| | T | Declared Free Agent (OL Matt Nelson declared free agency.) |
| | CB | Declared Free Agent (DB Will Harris declared free agency.) |
| | RB | Declared Free Agent (RB Jamaal Williams declared free agency.) |
| | DL | Declared Free Agent (DL John Cominsky declared free agency.) |
| | CB | Declared Free Agent (DB Amani Oruwariye declared free agency.) |
| | RB | Declared Free Agent (RB Justin Jackson declared free agency.) |
| | RB | Signed (The Detroit Lions signed RB David Montgomery.) |
| | C | Declared Free Agent (OL Evan Brown declared free agency.) |
| | DL | Declared Free Agent (DL Austin Bryant declared free agency.) |
| | LB | Declared Free Agent (LB Josh Woods declared free agency.) |
| | S | Declared Free Agent (DB DeShon Elliott declared free agency.) |
| | CB | Declared Free Agent (DB Mike Hughes declared free agency.) |
| | QB | Declared Free Agent (QB Nate Sudfeld declared free agency.) |
| | LB | Declared Free Agent (LB Chris Board declared free agency.) |
| | DL | Released (The Detroit Lions released DL Micheal Brockers.) |
| | CB | Signed (The Detroit Lions signed CB Mac McCain.) |
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