Spurs would help put Arsenal in the driving seat to win the title with victory over Pep Guardiola’s side on Tuesday.
Arsenal are one point ahead of City, whose game in hand is in north London on Tuesday.
Welch will be taking charge of the showpiece match for the first time.
The 27-year-old Netherlands international has scored 125 goals and provided 50 assists in 172 appearances for the Gunners.