| | DL | Pract. squad add (The San Francisco 49ers signed DE Jonathan Garvin to the practice squad.) |
| | CB | Pract. squad add (The San Francisco 49ers assigned CB Nick McCloud to the practice squad.) |
| | S | Pract. squad add (The San Francisco 49ers assigned SAF Tashaun Gipson Sr. to the practice squad.) |
| | DL | Activated (The San Francisco 49ers activated DE Yetur Gross-Matos from the IRD.) |
| | S | Activated (The San Franciso 49ers elevated SAF Tashaun Gipson Sr. to the active roster.) |
| | CB | Placed on Injured Reserve (The San Francisco 49ers placed CB Darrell Luter Jr. on the IR.) |
| | P | Activated (The San Francisco 49ers elevated P Pat O'Donnell to the active roster.) |
| | P | Placed on Injured Reserve (The San Francisco 49ers placed K Mitch Wishnowsky on the IR.) |
| | CB | Activated (The San Francisco 49ers elevated CB Nick McCloud to the active roster.) |
| | K | Waived (The San Francisco 49ers waived K Matthew Wright.) |
| | DL | Released (The San Francisco 49ers released DL T.Y. McGill.) |
| | P | Pract. squad add (The San Francisco 49ers signed P Pat O'Donnell to the practice squad.) |
| | RB | Pract. squad add (The San Francisco 49ers signed RB Patrick Taylor Jr. to the practice squad.) |
| | RB | Released (The San Francisco 49ers released RB Ke'Shawn Vaughn.) |
| | S | Released (The San Francisco 49ers released SAF Adrian Amos.) |
| | CB | Signed (The San Francisco 49ers signed CB Nick McCloud to the practice squad.) |
| | S | Pract. squad add (The San Francisco 49ers assigned SAF Tashaun Gipson Sr. to the practice squad.) |
| | RB | Waived (The San Francisco 49ers waived RB Patrick Taylor Jr.) |
| | RB | Activated (The San Francisco 49ers activated RB Christian McCaffrey from the IR.) |
| | S | Activated (The San Francisco 49ers elevated SAF Tashaun Gipson to the active roster.) |
| | S | Activated (The San Francisco 49ers activated S Adrian Amons.) |
| | LB | Pract. squad add (The San Francisco 49ers signed LB Jalen Graham to the practice squad.) |
| | OL | Released (The San Francisco 49ers released OL Dieter Eiselen.) |
| | DL | Placed on Injured Reserve, Designated for Return (The San Francisco 49ers placed DL Yetur Gross-Matos on IRD.) |
| | WR | Released (The San Francisco 49ers released WR Malik Turner.) |
| | WR | Pract. squad add (The San Francisco 49ers signed WR Russell Gage to the practice squad.) |
| | S | Pract. squad add (The San Francisco 49ers signed S Tashaun Gipson Sr. to the practice squad.) |
| | K | Released (The San Francisco 49ers released K Anders Carlson.) |
| | DT | Traded (The Houston Texans traded DT Khalil Davis to the San Francisco 49ers.) From |
| | LB | Waived (The San Francisco 49ers waived LB Jalen Graham.) |
| | S | Pract. squad add (The San Francisco 49ers assigned SAF Adrian Amos to the practice squad.) |
| | K | Pract. squad add (The San Francisco 49ers assigned K Anders Carlson to the practice squad.) |
| | S | Activated (The San Francisco 49ers elevated SAF Adrian Amos to the active roster.) |
| | K | Activated (The San Francisco 49ers elevated K Anders Carlson to the active roster.) |
| | DL | Released (The San Francisco 49ers released DL Jonathan Garvin.) |
| | DT | Pract. squad add (The San Francisco 49ers signed DT Nesta Jade Silvera to the practice squad.) |
| | WR | Pract. squad add (The San Francisco 49ers signed WR Malik Turner to the practice squad.) |
| | OL | Pract. squad add (The San Francisco 49ers signed OL Dieter Eiselen to the practice squad.) |
| | WR | Placed on Injured Reserve (The San Francisco 49ers placed WR Brandon Aiyuk on IR.) |
| | DL | Signed (The San Francisco 49ers signed DL Evan Anderson to the active roster from the practice squad.) |
| | K | Pract. squad add (The San Francisco 49ers assigned K Anders Carlson to the practice squad.) |
| | S | Pract. squad add (The San Francisco 49ers assigned SAF Jaylen Mahoney to the practice squad.) |
| | WR | Activated (The San Francisco 49ers activated WR Ricky Pearsall from the IRD.) |
| | K | Placed on Injured Reserve (The San Francisco 49ers placed K Matthew Wright on injured reserve.) |
| | K | Activated (The San Francisco 49ers elevated K Anders Carlsen from the practice squad.) |
| | OT | Claimed (The New York Giants claimed OL Chris Hubbard from the San Francisco 49ers practice squad.) To |
| | WR | Placed on Injured Reserve, Designated for Return (The San Francisco 49ers placed WR Ricky Pearsall on the IRD.) |
| | K | Pract. squad add (The San Francisco 49ers signed K Anders Carlson to the practice squad.) |
| | S | Pract. squad add (The San Francisco 49ers signed SAF Adrian Amos to the practice squad.) |
| | WR | Released (The San Francisco 49ers released WR Terrace Marshall.) |
| | DL | Activated (The San Francisco 49ers elevated DL Evan Anderson to the active roster from the practice squad.) |
| | S | Activated (The San Francisco 49ers elevated S Jaylen Mahoney to the active roster from the practice squad.) |
| | TE | Signed (The San Francisco 49ers signed TE Brayden Willis to the active roster from the practice squad.) |
| | S | Placed on Injured Reserve (The San Francisco 49ers placed SAF Talanoa Hufanga on IR.) |
| | K | Signed (The San Francisco 49ers signed K Matthew Wright.) |
| | WR | Pract. squad add (The San Francisco 49ers assigned WR Trent Taylor to the practice squad.) |
| | DL | Pract. squad add (The San Francisco 49ers assigned DL T.Y. McGill to the practice squad.) |
| | WR | Activated (The San Francisco 49ers elevated WR Trent Taylor from the practice squad.) |
| | DL | Activated (The San Francisco 49ers elevated DL T.Y. McGill from the practice squad.) |
| | DL | Placed on Injured Reserve (The San Francisco 49ers plaved DL Yetur Gross-Matos on the IR.) |
| | DL | Activated (The San Francisco 49ers activated DL Kalia Davis from the IR.) |
| | WR | Pract. squad add (The San Francisco 49ers signed WR Terique Owens to the practice squad.) |
| | DL | Pract. squad add (The San Francisco 49ers signed DL Jonathan Garvin to the practice squad.) |
| | DT | Released (The San Francisco 49ers released DL Shakel Brown.) |
| | LB | Claimed (The San Francisco 49ers claimed LB Jalen Graham from the Washington Commanders practice squad.) From |
| | DL | Pract. squad add (The San Francisco 49ers assigned DL Evan Anderson to the practice squad.) |
| | S | Pract. squad add (The San Francisco 49ers assigned SAF Jaylen Mahoney to the practice squad.) |
| | DL | Activated (The San Francisco 49ers elevated DL Evan Anderson from the practice squad.) |
| | LB | Placed on Injured Reserve (The San Francisco 49ers placed LB Curtis Robinson on the IR.) |
| | DL | Placed on Injured Reserve (The San Francisco 49ers placed DL Javon Hargrave on the IR.) |
| | DL | Signed (The San Francisco 49ers signed DE Sam Okuayinonu to the active roster.) |
| | S | Activated (The San Francisco 49ers elevated DB Jaylen Mahoney from the practice roster.) |
| | DT | Pract. squad add (The San Francisco 49ers signed DL Shakel Brown to the practice squad.) |
| | S | Released (The San Francisco 49ers released SAF Tracy Walker III.) |
| | TE | Pract. squad add (The San Francisco 49ers signed TE Brayden Willis to the practice squad.) |
| | DL | Pract. squad add (The San Francisco 49ers signed DL Sam Okuayinonu to the practice squad.) |
| | TE | Activated (The San Francisco 49ers elevated TE Brayden Willis to the active roster from the practice squad.) |
| | DL | Activated (The San Francisco 49ers elevated DL Sam Okuayinonu to the active roster from the practice squad.) |
| | S | Pract. squad add (The San Francisco 49ers signed SAF Tracy Walker III to the practice squad.) |
| | S | Activated (The San Francisco 49ers elevated Tracy Walker III from the practice squad.) |
| | RB | Placed on Injured Reserve (The San Francisco 49ers placed RB Christian McCaffrey on IR.) |
| | OT | Pract. squad add (The San Francisco 49ers signed OL Chris Hubbard to the practice squad.) |
| | S | Pract. squad add (The San Francisco 49ers signed SAF Tracy Walker III to the practice squad.) |
| | DL | Pract. squad add (The San Francisco 49ers signed DL Sam Okuayinonu to the practice squad.) |
| | DL | Released (The San Francisco 49ers released DL Jonathan Garvin.) |
| | DL | Activated (The San Francisco 49ers elevated DL Sam Okuayinonu to the active roster from the practice squad.) |
| | OT | Released (The San Francisco 49ers released OL Brandon Parker.) |
| | OT | Activated (The San Francisco 49ers activated T Trent Williams from non-football injury list.) |
| | S | Activated (The San Francisco 49ers elevated S Tracy Walker III to the active roster from the practice squad.) |
| | WR | Released (The San Francisco 49ers released WR Tay Martin.) |
| | OT | Signed (The San Francisco 49ers signed OL Brandon Parker.) |
| | T | Released (The San Francisco 49ers release OL Sebastian Gutierrez.) |
| | DL | Pract. squad add (The San Francisco 49ers assigned DL Sam Okuayinonu to the practice squad.) |
| | LB | Pract. squad add (The San Francisco 49ers signed LB DaShaun White to the practice squad.) |
| | WR | Reserve/non football injury (The San Francisco 49ers placed WR Ricky Pearsall on the non-football injury list.) |
| | RB | Pract. squad add (The San Francisco 49ers signed RB Ke'Shawn Vaughn to the practice squad.) |
| | CB | Signed (The San Francisco 49ers signed CB Rock Ya-Sin.) |
| | OL | Signed (The San Francisco 49ers signed OL Ben Bartch.) |
| | TE | Signed (The San Francisco 49ers signed TE Eric Saubert.) |
| | WR | Pract. squad add (The San Francisco 49ers signed WR Terrace Marshall Jr. to the practice squad.) |
| | OG | Claimed (The Carolina Panthers claimed OL Jarrett Kingston off waivers.) To |
| | DL | Pract. squad add (The San Francisco 49ers signed DL Jonathan Garvin to the practice squad.) |
| | WR | Pract. squad add (The San Francisco 49ers signed WR Trent Taylor to the practice squad.) |
| | CB | Pract. squad add (The San Francisco 49ers signed CB Chase Lucas to the practice squad.) |
| | CB | Claimed (The Indianapolis Colts claimed CB Samuel Womack III off waivers.) To |
| | DL | Pract. squad add (The San Francisco 49ers signed DL T.Y. McGill to the practice squad.) |
| | TE | Pract. squad add (The San Francisco 49ers signed TE Mason Pline to the practice squad.) |
| | DL | Pract. squad add (The San Francisco 49ers signed DL Evan Anderson to the practice squad.) |
| | OL | Pract. squad add (The San Francisco 49ers signed OL Drake Nugent to the practice squad.) |
| | S | Pract. squad add (The San Francisco 49ers signed S Jaylen Mahoney to the practice squad.) |
| | DL | Pract. squad add (The San Francisco 49ers signed DL Alex Barrett to the practice squad.) |
| | S | Pract. squad add (The San Francisco 49ers signed S Tracy Walker III to the practice squad.) |
| | TE | Pract. squad add (The San Francisco 49ers signed TE Brayden Willis to the practice squad.) |
| | RB | Claimed (The Los Angeles Rams claimed RB Cody Schrader off waivers.) To |
| | QB | Pract. squad add (The San Francisco 49ers signed QB Tanner Mordecai to the practice squad.) |
| | OL | Pract. squad add (The San Francisco 49ers signed OL Isaac Alarcon to the practice squad.) |
| | T | Pract. squad add (The San Francisco 49ers signed OL Sebastian Gutierrez to the practice squad.) |
| | WR | Waived (The San Francisco 49ers waived WR Tay Martin.) |
| | CB | Waived (The San Francisco 49ers waived CB Chase Lucas.) |
| | CB | Waived (The San Francisco 49ers waived CB Samuel Womack III.) |
| | TE | Released (The San Francisco 49ers released TE Logan Thomas.) |
| | RB | Waived (The San Francisco 49ers waived RB Cody Schrader.) |
| | T | Waived (The San Francisco 49ers waived OL Sebastian Gutierrez.) |
| | RB | Placed on Injured Reserve (The San Francisco 49ers placed RB Elijah Mitchell on injured reserve.) |
| | DL | Waived (The San Francisco 49ers waived DL Evan Anderson.) |
| | TE | Waived (The San Francisco 49ers waived TE Cameron Latu.) |
| | OT | Released (The San Francisco 49ers released OL Brandon Parker.) |
| | DL | Released (The San Francisco 49ers released DL T.Y. McGill Jr.) |
| | S | Waived (The San Francisco 49ers waived SAF Jaylen Mahoney.) |
| | QB | Waived (The San Francisco 49ers waived QB Tanner Mordecai.) |
| | OL | Waived (The San Francisco 49ers waived OL Drake Nugent.) |
| | S | Released (The San Francisco 49ers released SAF Tracy Walker III.) |
| | CB | Released (The San Francisco 49ers released CB Jason Verrett.) |
| | S | Activated (The San Francisco 49ers activated SAF Talanoa Hufanga from the PUP list.) |
| | DT | Released (The San Francisco 49ers released DL Nick Williams.) |
| | DT | Waived (The San Francisco 49ers waived DL Shakel Brown.) |
| | OL | Waived (The San Francisco 49ers waived OL Isaac Alarcon.) |
| | CB | Released (The San Francisco 49ers released CB Rock Ya-Sin.) |
| | LB | Waived (The San Francisco 49ers waived LB Jalen Graham.) |
| | TE | Waived (The San Francisco 49ers waived TE Mason Pline.) |
| | TE | Released (The San Francisco 49ers released TE Eric Saubert.) |
| | OT | Released (The San Francisco 49ers waived OL Chris Hubbard.) |
| | WR | Waived (The San Francisco 49ers waived WR Danny Gray.) |
| | DL | Placed on Injured Reserve, Designated for Return (The San Francisco 49ers placed DL Kalia Davis on the IRD list.) |
| | TE | Waived (The San Francisco 49ers waived TE Brayden Willis.) |
| | DL | Waived (The San Francisco 49ers waived DL Alex Barrett.) |
| | WR | Released (The San Francisco 49ers released WR Trent Taylor.) |
| | OG | Waived (The San Francisco 49ers waived OL Jarrett Kingston.) |
| | DL | Waived (The San Francisco 49ers waived DL Jonathan Garvin.) |
| | WR | Released (The San Francisco 49ers released WR Jontre Kirklin.) |
| | RB | Released (The San Francisco 49ers released RB Ke'Shawn Vaughn.) |
| | RB | Released (The San Francisco 49ers released RB Matt Breida.) |
| | TE | Signed (The San Francisco 49ers signed TE Logan Thomas.) |
| | S | Placed on Injured Reserve (The San Francisco 49ers placed S Tayler Hawkins on IR after being waived due to injury.) |
| | TE | Signed (The San Francisco 49ers signed TE Logan Thomas.) |
| | S | Waived Injury (The San Francisco 49ers waived S Tayler Hawkins due to injury.) |
| | WR | Waived Injury (The San Francisco 49ers waived WR Terique Owens due to injury.) |
| | DL | Waived Injury (The San Francisco 49ers waived DL Austin Bryant due to injury.) |
| | LB | Released (The San Francisco 49ers released DL Ezekiel Turner.) |
| | DT | Signed (The San Francisco 49ers signed DT Nicholas Williams.) |
| | DT | Signed (The San Francisco 49ers signed DL Nick Williams.) |
| | WR | Waived Injury (The San Francisco 49ers waived WR Frank Darby due to injury.) |
| | WR | Placed on Injured Reserve (The San Francisco 49ers placed WR Terique Owens on IR.) |
| | C | Waived Injury (The San Francisco 49ers waived C Pat Elflein due to injury.) |
| | P | Signed (The San Francisco 49ers signed P Pressley Harvin III.) |
| | DL | Placed on Injured Reserve (The San Francisco 49ers placed DL Austin Bryant on IR.) |
| | TE | Released (The San Francisco 49ers released TE Logan Thomas.) |
| | WR | Signed (The San Francisco 49ers signed WR Robbie Chosen.) |
| | DL | Signed (The San Francisco 49ers signed DE Jonathan Garvin.) |
| | S | Signed (The San Francisco 49ers signed S Tracy Walker III.) |
| | WR | Waived Injury (The San Francisco 49ers waived WR Terique Jones due to injury.) |
| | RB | Signed (The San Francisco 49ers signed RB Ke'Shawn Vaughn.) |
| | S | Released (The San Francisco 49ers released S Erik Harris.) |
| | WR | Signed (The San Francisco 49ers signed WR Jontre Kirklin.) |
| | RB | Signed (The San Francisco 49ers signed RB Matt Breida.) |
| | WR | Placed on Injured Reserve (The San Francisco 49ers placed WR Malik Turner on IR.) |
| | C | Placed on Injured Reserve (The San Francisco 49ers placed OL Pat Elflein on IR.) |
| | OL | Signed (The San Francisco 49ers signed G Lewis Kidd.) |
| | OL | Waived (The San Francisco 49ers waived OL Briason Mays.) |
| | C | Signed (The San Francisco 49ers signed OL Pat Elflein.) |
| | WR | Activated (The San Francisco 49ers activated WR Ricky Pearsall from the non-football injury list.) |
| | WR | Signed (The San Francisco 49ers signed WR Frank Darby.) |
| | CB | Waived (The San Francisco 49ers waived DB Kemon Hall.) |
| | OT | Reserve/non football injury (The San Francisco 49ers placed T Trent Williams on the Non-football injured list.) |
| | WR | Signed (The San Francisco 49ers signed WR Malik Turner.) |
| | DL | Placed on PUPL (The San Francisco 49ers placed DL Drake Jackson on the Physically Unable to Perform list.) |
| | S | Placed on PUPL (The San Francisco 49ers placed S Talanoa Hufanga on the Physically Unable to Perform list.) |
| | LB | Placed on PUPL (The San Francisco 49ers placed LB Dre Greenlaw on the Physically Unable to Perform list.) |
| | WR | Reserve/non football injury (The San Francisco 49ers placed WR Ricky Pearsall on the Non-football injured list.) |
| | WR | Signed (The San Francisco 49ers signed WR Ricky Pearsall.) |
| | TE | Signed (The San Francisco 49ers signed TE Logan Thomas.) |
| | DE | Waived (The San Francisco 49ers waived DL Raymond Johnson III.) |
| | OG | Signed (The San Francisco 49ers signed OL Jarrett Kingston.) |
| | OL | Waived (The San Francisco 49ers waived OL Corey Luciano.) |
| | DT | Signed (The San Francisco 49ers signed DL Shakel Brown.) |
| | OT | Signed (The San Francisco 49ers signed OL Chris Hubbard.) |
| | DE | Waived (The San Francisco 49ers waived DL Earnest Brown IV.) |
| | OL | Signed (The San Francisco 49ers signed OL Dominick Puni.) |
| | S | Signed (The San Francisco 49ers signed S Malik Mustapha.) |
| | LB | Signed (The San Francisco 49ers signed LB Tatum Bethune.) |
| | DL | Released (The San Francisco 49ers released DL Spencer Waege.) |
| | S | Signed (The San Francisco 49ers signed DB Jaylen Mahoney.) |
| | OL | Signed (The San Francisco 49ers signed C Briason Mays.) |
| | TE | Signed (The San Francisco 49ers signed TE Mason Pline.) |
| | OL | Signed (The San Francisco 49ers signed OL Drake Nugent.) |
| | QB | Signed (The San Francisco 49ers signed QB Tanner Mordecai.) |
| | RB | Signed (The San Francisco 49ers signed RB Cody Schrader.) |
| | WR | Signed (The San Francisco 49ers signed WR Terique Owens.) |
| | DL | Signed (The San Francisco 49ers signed DL Evan Anderson.) |
| | WR | Signed (The San Francisco 49ers signed WR Trent Taylor. ) |
| | CB | Signed (The San Francisco 49ers signed CB Rock Ya-Sin.) From |
| | TE | Signed (The San Francisco 49ers signed TE Eric Saubert.) |
| | RB | Signed (The San Francisco 49ers signed RB Patrick Taylor.) |
| | OLB | Signed (The Tampa Bay Buccaneers signed LB Randy Gregory.) To |
| | QB | Signed (The San Francisco 49ers signed QB Joshua Dobbs.) |
| | DL | Declared Free Agent (DT Sebastian Joseph-Day elected free agency.) |
| | DE | Declared Free Agent (DL Chase Young elected free agency.) |
| | CB | Signed (The San Francisco 49ers signed CB Chase Lucas.) |
| | OT | Signed (The San Francisco 49ers signed T Brandon Parker.) |
| | LB | Signed (The San Francisco 49ers signed LB Ezekiel Turner.) |
| | CB | Signed (The San Francisco 49ers signed CB Isaac Yiadom.) |
| | LB | Declared Free Agent (San Francisco 49ers LB Oren Burks declared free agency.) |
| | LB | Signed (The San Francisco 49ers signed LB De'Vondre Campbell.) |
| | WR | Declared Free Agent (San Francisco 49ers WR Ray-Ray McCloud declared free agency.) |
| | DL | Traded (The Houston Texans traded DT Maliek Collins to the San Francisco 49ers.) From |
| | OL | Declared Free Agent (San Francisco 49ers OL Matt Pryor declared free agency.) |
| | DL | Signed (The San Francisco 49ers signed DT Jordan Elliott.) |
| | QB | Declared Free Agent (QB Sam Darnold elected free agency.) |
| | DL | Signed (The San Francisco 49ers signed OLB Yetur Gross-Matos.) |
| | DT | Declared Free Agent (DT Javon Kinlaw elected free agency.) |
| | DE | Declared Free Agent (DL Clelin Ferrell declared free agency.) |
| | DL | Signed (The San Francisco 49ers signed DE Leonard Floyd.) |
| | DE | Released (The San Francisco 49ers released DT Arik Armstead.) |
| | TE | Declared Free Agent (TE Charlie Woerner elected free agency.) |
| | CB | Released (The San Francisco 49ers released CB Isaiah Oliver.) |
| | RB | Signed (The Philadelphia Eagles signed RB Tyrion Davis-Price to a reserve/future contract.) To |
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