When T.J. Watt exited last week's game with an injury, Anthony Chickillo came in, even though Harrison is second on the depth chart.
Not every school can be like No. 2 Clemson, which is going for a second straight national championship despite replacing two-time Heisman Trophy finalist Deshaun Watson at quarterback. Across the Atlantic Coast Conference, schools are struggling with new QBs - some freshmen or sophomores, others upperclassman playing for the first time. Clemson (3-0, 1-0 ACC) has had success with junior Kelly Bryant, and No. 13 Virginia Tech (3-0) is rolling behind redshirt freshman Josh Jackson .
The Patriots, Packers and Steelers are the biggest betting favorites in Week 3.