| | WR | Signed (The Indianapolis Colts signed WR Isaiah McKenzie.) |
| | CB | Traded (The Indianapolis Colts traded CB Stephon Gilmore to the Dallas Cowboys.) To |
| | QB | Signed (The Indianapolis Colts signed QB Gardner Minshew.) |
| | K | Signed (The Indianapolis Colts signed K Matt Gay.) |
| | CB | Re-signed (The Indianapolis Colts re-signed CB Tony Brown.) |
| | WR | Re-signed (The Indianapolis Colts re-signed WR Ashton Dulin.) |
| | P | Declared Free Agent (P Matt Haack declared free agency. ) |
| | CB | Declared Free Agent (CB Tony Brown declared free agency.) |
| | DE | Declared Free Agent (DE Ben Banogu declared free agency.) |
| | WR | Declared Free Agent (WR Ashton Dulin declared free agency.) |
| | LB | Signed (The Indianapolis Colts signed LB E.J. Speed.) |
| | T | Declared Free Agent (OT Dennis Kelly declared free agency.) |
| | LB | Declared Free Agent (LB E.J. Speed declared free agency.) |
| | K | Declared Free Agent (K Chase McLaughlin declared free agency.) |
| | CB | Declared Free Agent (CB Brandon Facyson declared free agency.) |
| | WR | Declared Free Agent (WR Parris Campbell declared free agency.) |
| | DE | Declared Free Agent (DE Yannick Ngakoue declared free agency.) |
| | S | Declared Free Agent (S Armani Watts declared free agency.) |
| | CB | Traded (The Indianapolis Colts traded CB Stephon Gilmore to the Dallas Cowboys.) To |
| | WR | Declared Free Agent (WR Kristian Wilkerson declared free agency.) |
| | T | Declared Free Agent (OT Matt Pryor declared free agency.) |
| | DT | Declared Free Agent (DT Byron Cowart declared free agency.) |
| | LB | Signed (The Indianapolis Colts signed DE Samson Ebukam.) |
| | QB | Released (The Indianapolis Colts released QB Matt Ryan.) |
| | LB | Declared Free Agent (LB Bobby Okereke declared free agency.) |
| | S | Declared Free Agent (S Rodney McLeod Jr. declared free agency.) |
| | WR | Signed (The Indianapolis Colts signed WR Malik Turner.) |
| | WR | Claimed (The Indianapolis Colts claimed WR Kristian Wilkerson.) |
| | WR | Signed (The Indianapolis Colts signed WR Ethan Fernea to a reserve/future contract.) |
| | C | Claimed (The Indianapolis Colts claimed C Dakoda Shepley off waivers from the Dallas Cowboys. ) |
| | LB | Signed (The Indianapolis Colts signed LB Forrest Rhyne to a reserve/futures contract.) |
| | S | Signed (The Indianapolis Colts signed SAF Marcel Dabo to a reserve/futures contract.) |
| | CB | Signed (The Indianapolis Colts signed CB David Vereen to a reserve/futures contract.) |
| | WR | Pract. squad add (The Indianapolis Colts assigned WR Keke Coutee to the practice squad.) |
| | DT | Signed (The Indianapolis Colts signed DT McTelvin Agim to a reserve/futures contract.) |
| | S | Signed (The Indianapolis Colts signed SAF Trevor Denbow to a reserve/futures contract.) |
| | G | Signed (The Indianapolis Colts signed OG Arlington Hambright to a reserve/futures contract.) |
| | LB | Signed (The Indianapolis Colts signed LB Segun Olubi to a reserve/futures contract.) |
| | WR | Signed (The Indianapolis Colts signed WR Vyncint Smith to a reserve/futures contract.) |
| | S | Signed (The Indianapolis Colts signed SAF Henry Black to a reserve/futures contract.) |
| | TE | Signed (The Indianapolis Colts signed TE Jalen Wydermyer to a reserve/futures contract.) |
| | S | Pract. squad add (The Indianapolis Colts assigned DB Trevor Denbow to the practice squad.) |
| | RB | Signed (The Indianapolis Colts signed RB Aaron Shampklin to a reserve/futures contract.) |
| | T | Signed (The Indianapolis Colts signed OT Jordan Murray to a reserve/futures contract.) |
| | WR | Activated (The Indianapolis Colts elevated WR Keke Coutee from the practice squad.) |
| | S | Activated (The Indianapolis Colts activated S Trevor Denbow.) |
| | DE | Signed (The Indianapolis Colts signed DL Rashod Berry.) From |
| | CB | Placed on Injured Reserve (The Indianapolis Colts placed DB Kenny Moore II on IR.) |
| | RB | Waived (The Indianapolis Colts waived RB Jordan Wilkins.) |
| | RB | Activated (The Indianapolis Colts elevated RB Jake Funk to the active roster.) |
| | DB | Signed (The Indianapolis Colts signed DB Sheldrick Redwine to the practice squad.) |
| | LB | Pract. squad add (The Indianapolis Colts assigned LB Segun Olubi to the practice squad.) |
| | WR | Pract. squad add (The Indianapolis Colts assigned WR Keke Coutee to the practice squad.) |
| | DE | Signed (The Indianapolis Colts signed DE Kameron Cline to the active roster.) |
| | LB | Activated (The Indianapolis Colts elevated LB Segun Olubi to the active roster.) |
| | WR | Activated (The Indianapolis Colts elevated WR Keke Coutee to the active roster.) |
| | DE | Placed on Injured Reserve (The Indianapolis Colts placed DE Yannick Ngakoue on injured reserve.) |
| | TE | Released (The Indianapolis Colts released TE Dominique Dafney.) |
| | WR | Signed (The Indianapolis Colts signed WR keke Coutee to the practice squad.) |
| | CB | Placed on Injured Reserve (The Indianapolis Colts placed DB Isaiah Rodgers Sr. on IR.) |
| | CB | Activated (The Indianapolis Colts elevated DB Darrell Baker Jr. to the active roster.) |
| | CB | Signed (The Indianapolis Colts signed DB David Vereen to the practice squad.) |
| | LB | Pract. squad add (The Indianapolis Colts assigned LB Segun Olubi to the practice squad.) |
| | LB | Activated (The Indianapolis Colts elevated LB Segun Olubi to the active roster.) |
| | RB | Signed (The Indianapolis Colts signed RB Jordan Wilkins to the active roster.) |
| | RB | Signed (The Indianapolis Colts signed RB Aaron Shampklin to the practice squad.) |
| | TE | Signed (The Indianapolis Colts signed TE Dominique Dafney to the practice squad.) |
| | DE | Waived (The Indianapolis Colts waived DL Ifeadi Odenigbo.) |
| | RB | Placed on Injured Reserve (The Indianapolis Colts placed RB Jonathan Taylor on IR.) |
| | LB | Signed (The Indianapolis Colts signed LB Cameron McGrone.) From |
| | DT | Released (The Indianapolis Colts released DL Curtis Brooks.) |
| | CB | Activated (The Indianapolis Colts elevated CB Darrell Baker to the active roster.) |
| | WR | Signed (The Indianapolis Colts signed WR Robert Foster to the practice squad.) |
| | LB | Activated (The Indianapolis Colts elevated LB Forrest Rhyne to the active roster.) |
| | WR | Released (The Indianapolis Colts released WR Robert Foster.) |
| | DT | Signed (The Indianapolis Colts signed DL McTelvin Agim to the practice squad.) |
| | WR | Signed (The Indianapolis Colts signed WR Robert Foster to the practice squad.) |
| | WR | Waived (The Indianapolis Colts waived WR Keke Coutee.) |
| | TE | Signed (The Indianapolis Colts elevated TE Nikola Kalinic to the active roster.) |
| | LB | Pract. squad add (The Indianapolis Colts assigned LB Forrest Rhyne to the practice squad.) |
| | LB | Activated (The Indianapolis Colts elevated LB Forrest Rhyne from the practice squad.) |
| | LB | Pract. squad add (Signed) |
| | TE | Pract. squad add (Signed) |
| | TE | Active/prac. squad (Signed) |
| | LB | Active/prac. squad (Signed) |
| | S | Pract. squad add (Signed) |
| | S | Cut (Signed) |
| | DE | Active/prac. squad (Signed) From |
| | LB | Pract. squad del (Signed) |
| | DT | Pract. squad add (Signed) To |
| | TE | Pract. squad add (Signed) |
| | DE | Pract. squad add (Signed) |
| | TE | Active/prac. squad (Signed) |
| | DE | Active/prac. squad (Signed) |
| | TE | Pract. squad del (Signed) |
| | LB | Pract. squad add (Signed) From |
| | CB | Pract. squad add (Signed) To |
| | RB | Pract. squad add (Signed) |
| | TE | Pract. squad add (Signed) |
| | TE | Active/prac. squad (Signed) |
| | RB | Active/prac. squad (Signed) |
| | RB | Pract. squad add (Signed) From |
| | RB | Pract. squad del (Signed) |
| | RB | Pract. squad del (Signed) |
| | TE | Pract. squad add (Signed) From |
| | RB | Pract. squad add (Signed) |
| | RB | Pract. squad add (Signed) |
| | P | Pract. squad add (Signed) To |
| | RB | Active/prac. squad (Signed) |
| | RB | Active/prac. squad (Signed) |
| | RB | Pract. squad add (Signed) From |
| | RB | Traded (for RB Zack Moss and 2023 draft pick) To |
| | RB | Traded (w/ pick for RB Nyheim Hines) From |
| | P | Pract. squad del (Signed) |
| | CB | Pract. squad add (Signed) To |
| | WR | Pract. squad add (Signed) To |
| | LB | Pract. squad add (Signed) |
| | CB | Pract. squad del (Signed) |
| | P | Pract. squad add (Signed) From |
| | WR | Pract. squad del (Signed) |
| | WR | Pract. squad add (Signed) |
| | WR | Pract. squad add (Signed) |
| | WR | Active/prac. squad (Signed) |
| | WR | Active/prac. squad (Signed) |
| | K | Pract. squad add (Signed) To |
| | T | Active/prac. squad (Signed) To |
| | WR | Pract. squad add (Signed) |
| | RB | Pract. squad add (Signed) |
| | RB | Pract. squad add (Signed) |
| | T | Acquired from waiver (Signed) To |
| | TE | Pract. squad del (Signed) |
| | TE | Pract. squad add (Signed) From |
| | WR | Pract. squad add (Signed) From |
| | RB | Active/prac. squad (Signed) |
| | RB | Active/prac. squad (Signed) |
| | T | Cut (Signed) |
| | WR | Active/prac. squad (Signed) |
| | LS | Pract. squad add (Signed) To |
| | RB | Pract. squad add (Signed) To |
| | T | Pract. squad add (Signed) From |
| | DT | Active/prac. squad (Signed) |
| | RB | Pract. squad add (Signed) |
| | DT | Pract. squad add (Signed) |
| | DT | Active/prac. squad (Signed) |
| | RB | Active/prac. squad (Signed) |
| | C | Pract. squad add (Signed) To |
| | WR | Pract. squad add (Signed) |
| | K | Active/prac. squad (Signed) |
| | WR | Cut (Signed) |
| | DT | Pract. squad add (Signed) |
| | K | Pract. squad add (Signed) |
| | K | Pract. squad add (Signed) To |
| | DT | Active/prac. squad (Signed) |
| | K | Active/prac. squad (Signed) |
| | CB | Pract. squad add (Signed) To |
| | CB | Pract. squad add (Signed) From |
| | LB | Pract. squad del (Signed) |
| | K | Pract. squad add (Signed) |
| | K | Active/prac. squad (Signed) |
| | K | Pract. squad del (Signed) |
| | G | Pract. squad add (Signed) |
| | TE | Pract. squad add (Signed) From |
| | TE | Pract. squad del (Signed) |
| | K | Pract. squad add (Signed) |
| | WR | Pract. squad add (Signed) |
| | K | Active/prac. squad (Signed) |
| | WR | Active/prac. squad (Signed) |
| | CB | Pract. squad add (Signed) To |
| | K | Pract. squad add (Signed) |
| | K | Pract. squad add (Signed) From |
| | K | Cut (Signed) |
| | CB | Pract. squad del (Signed) |
| | CB | Pract. squad del (Signed) |
| | G | Pract. squad del (Signed) |
| | S | Pract. squad add (Signed) From |
| | CB | Pract. squad add (Signed) From |
| | CB | Active/prac. squad (Signed) |
| | CB | Pract. squad add (Signed) |
| | OLB | Re-signed (Four-year extension (through 2026)) |
| | CB | Active/prac. squad (Signed) |
| | RB | Pract. squad add (Signed) |
| | T | Pract. squad add (Signed) To |
| | CB | Pract. squad add (Signed) To |
| | LB | Pract. squad add (Signed) From |
| | G | Pract. squad add (Signed) From |
| | CB | Pract. squad add (Signed) To |
| | WR | Pract. squad add (Signed) |
| | DE | Pract. squad add (Signed) |
| | DT | Pract. squad add (Signed) |
| | CB | Pract. squad add (Signed) |
| | T | Signed (Signed) |
| | WR | Pract. squad add (Signed) |
| | LB | Pract. squad add (Signed) |
| | CB | Pract. squad add (Signed) |
| | S | Pract. squad add (International Player Pathway Program) |
| | CB | Cut (Signed) |
| | LB | Acquired from waiver (Signed) To |
| | RB | Pract. squad add (Signed) |
| | DT | Pract. squad add (Signed) |
| | T | Pract. squad add (Signed) |
| | T | Acquired from waiver (Signed) From |
| | CB | Pract. squad add (Signed) |
| | TE | Pract. squad add (Signed) |
| | TE | Pract. squad add (Signed) From |
| | RB | Cut (Signed) |
| | LB | Traded (w/ pick for 2023 sixth-round draft pick) From |
| | TE | Cut (Signed) |
| | WR | Cut (Signed) |
| | G | Cut (Signed) |
| | S | Cut (Signed) |
| | QB | Cut (Signed) |
| | WR | Cut (Signed) |
| | LB | Cut (Signed) |
| | DE | Cut (Signed) |
| | RB | Cut (Signed) |
| | CB | Cut (Signed) |
| | DT | Cut (Signed) |
| | WR | Cut (Signed) |
| | DT | Cut (Signed) |
| | T | Cut (Signed) |
| | CB | Cut (Signed) |
| | CB | Cut (Signed) |
| | LB | Cut (Signed) |
| | TE | Cut (Signed) |
| | RB | Cut (Signed) |
| | DT | Cut (Signed) |
| | WR | Cut (Signed) |
| | CB | Cut (Signed) |
| | T | Cut (Signed) |
| | LB | Cut (Signed) |
| | LB | Cut (Signed) |
| | T | Cut (Signed) |
| | K | Acquired from waiver (Signed) To |
| | K | Cut (Signed) |
| | P | Signed (Signed) From |
| | C | Cut (Signed) |
| | RB | Cut (Signed) |
| | DT | Cut (Signed) |
| | WR | Cut (Signed) |
| | WR | Cut (Signed) |
| | CB | Cut (Signed) |
| | T | Cut (Signed) |
| | WR | Cut (Signed) |
| | OLB | Cut (Signed) |
| | DB | Signed (Signed) To |
| | WR | Cut (Signed) |
| | RB | Signed (Signed) To |
| | WR | Signed (Signed) From |
| | C | Signed (Signed) |
| | DT | Signed/unrest FA (Signed) To |
| | DE | Cut (Signed) |
| | DT | Signed (Signed) |
| | DE | Signed (Signed) To |
| | DT | Cut (Signed) |
| | WR | Cut (Signed) |
| | WR | Signed (Signed) From |
| | WR | Signed/unrest FA (Signed) From |
| | S | Placed on PUPL (undisclosed) |
| | DE | Placed on PUPL (undisclosed) |
| | LB | Placed on PUPL (undisclosed) |
| | WR | Placed on PUPL (undisclosed) |
| | DE | Cut (Signed) |
| | DT | Acquired from waiver (Signed) From |
| | LB | Signed (Signed) To |
| | S | Retired (Signed) |
| | DE | Signed/unrest FA (Signed) From |
| | DE | Cut (Signed) |
| | OLB | Signed/unrest FA (Signed) From |
| | DE | Signed/unrest FA (Signed) From |
| | DT | Cut (Signed) |
| | LB | Cut (Signed) |
| | DT | Signed (Signed) |
| | QB | Signed (Signed) To |
| | C | Cut (Signed) |
| | RB | Signed/unrest FA (Signed) From |
| | QB | Signed (Two-year contract (through 2023)) From |
| | QB | Cut (Signed) |
| | T | Signed/draft choice (Four-year contract (through 2025)) |
| | TE | Signed/draft choice (Four-year contract (through 2025)) |
| | OLB | Signed (Signed) To |
| | RB | Cut (Signed) |
| | RB | Signed/unrest FA (One-year contract (through 2022)) From |
| | WR | Signed/draft choice (Four-year contract (through 2025)) |
| | C | Signed (Signed) |
| | DT | Signed (Signed) |
| | T | Signed (Signed) |
| | DE | Signed (Signed) |
| | WR | Signed (Signed) |
| | DE | Signed (Signed) |
| | LB | Signed (Signed) |
| | DB | Signed/draft choice (Four-year contract (through 2025)) |
| | G | Signed (Signed) |
| | CB | Signed (Signed) |
| | WR | Signed (Signed) |
| | DT | Signed/draft choice (Four-year contract (through 2025)) |
| | S | Signed/draft choice (Four-year contract (through 2025)) |
| | QB | Signed (Signed) |
| | LB | Signed (Signed) |
| | WR | Signed (Signed) |
| | WR | Signed (Signed) |
| | LB | Signed (Signed) |
| | TE | Signed/draft choice (Four-year contract (through 2025)) |
| | RB | Signed (Signed) |
| | RB | Signed (Signed) |
| | DT | Signed/draft choice (Four-year contract (through 2025)) |
| | RB | Signed (Signed) |
| | LB | Signed (Signed) |
| | C | Signed (Signed) |
| | S | Signed (Signed) |
| | TE | Acquired from waiver (Signed) To |
| | LB | Cut (Signed) |
| | OLB | Cut (Signed) |
| | T | Signed/unrest FA (Signed) From |
| | TE | Cut (Signed) |
| | TE | Cut (Signed) |
| | S | Signed (International Player Pathway Program) |
| | DT | Signed/unrest FA (One-year contract (through 2022)) To |
| | DE | Signed/unrest FA (One-year contract (through 2022)) To |
| | WR | Re-signed/rest FA (One-year contract (through 2022)) |
| | CB | Signed/unrest FA (Two-year contract (through 2023)) From |
| | T | Signed (One-year contract (through 2022)) From |
| | S | Signed/unrest FA (Signed) From |
| | DL | Signed/unrest FA (One-year contract (through 2022)) To |
| | LB | Signed/unrest FA (One-year contract (through 2022)) From |
| | RB | Signed/unrest FA (One-year contract (through 2022)) To |
| | LB | Signed/unrest FA (One-year contract (through 2022)) To |
| | DL | Signed/unrest FA (One-year contract (through 2022)) To |
| | OLB | Signed/unrest FA (Two-year contract (through 2023)) To |
| | S | Signed/unrest FA (One-year contract (through 2022)) From |
| | WR | Signed/unrest FA (One-year contract (through 2022)) To |
| | DB | Signed/unrest FA (Three-year contract (through 2024)) To |
| | QB | Traded (for 2022 third-round draft pick) From |
| | CB | Signed/unrest FA (One-year contract (through 2022)) From |
| | DL | Signed/unrest FA (Two-year contract (through 2023)) To |
| | OG | Signed/unrest FA (Three-year contract (through 2024)) To |
| | DL | Declared Free Agent (Signed) |
| | CB | Traded (for DE Yannick Ngakoue) To |
| | T | Declared Free Agent (Signed) |
| | T | Declared Free Agent (Signed) |
| | QB | Traded (for 2022 2nd and 2023 3rd-round picks) To |
| | DE | Traded (for CB Rock Ya-Sin) From |
| | FS | Declared Free Agent (Signed) |
| | DE | Re-signed (One-year contract (through 2022)) |
| | LB | Re-signed (Three-year contract (through 2024)) |
| | DT | Declared Free Agent (Signed) |
| | DL | Declared Free Agent (Signed) |
| | DT | Declared Free Agent (Signed) |
| | CB | Declared Free Agent (Signed) |
| | DE | Declared Free Agent (Signed) |
| | CB | Declared Free Agent (Signed) |
| | LB | Declared Free Agent (Signed) |
| | CB | Declared Free Agent (Signed) |
| | K | Declared Free Agent (Signed) |
| | WR | Declared Free Agent (Signed) |
| | OLB | Declared Free Agent (Signed) |
| | S | Declared Free Agent (Signed) |
| | WR | Declared Free Agent (Signed) |
| | LB | Declared Free Agent (Signed) |
| | DB | Declared Free Agent (Signed) |
| | OG | Declared Free Agent (Signed) |
| | DL | Declared Free Agent (Signed) |
| | WR | Restricted Free Agent (Signed) |
| | RB | Declared Free Agent (Signed) |
| | T | Re-signed (One-year extension (through 2022)) |
| | DT | Declared Free Agent (Signed) |
| | WR | Declared Free Agent (Signed) |
| | TE | Re-signed (Three-year contract (through 2024)) |
| | CB | Signed (Signed) From |
| | TE | Retired (Signed) |
| | TE | Signed (Signed) |
| | T | Signed (Signed) |
| | CB | Signed (Signed) |
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