| | S | Claimed (The Indianapolis Colts claimed SAF Darren Hall off waivers.) From |
| | C | Placed on Injured Reserve (The Indianapolis Colts placed C Ryan Kelly on IR.) |
| | WR | Released (The Indianapolis Colts released WR Ethan Fernea.) |
| | CB | Pract. squad add (The Indianapolis Colts signed CB Tre Flowers to the practice squad.) |
| | QB | Pract. squad add (The Indianapolis Colts reinstated QB Jason Bean to the practice Squad.) |
| | DT | Released (The Indianapolis Colts released DT Josiah Bronson.) |
| | CB | Released (The Indianapolis Colts released CB Kelvin Joseph.) |
| | RB | Pract. squad add (The Indianapolis Colts signed RB Evan Hull to the practice squad.) |
| | T | Pract. squad add (The Indianapolis Colts signed T Sebastian Gutierrez to the practice squad.) |
| | S | Placed on Injured Reserve (The Indianapolis Colts placed SAF Trevor Denbow on the IR.) |
| | T | Released (The Indianapolis Colts released T Jack Wilson.) |
| | CB | Pract. squad add (The Indianapolis Colts assigned CB Kelvin Joseph to the practice squad.) |
| | S | Signed (The Indianapolis Colts signed SAF Ronnie Harrison Jr. to the active roster.) |
| | G | Pract. squad add (The Indianapolis Colts signed G Sebastian Gutierrez to the practice squad.) |
| | LB | Placed on Injured Reserve (The Indianapolis Colts placed LB Jaylon Carlies on IR.) |
| | DT | Activated (The Indianapolis Colts activated DT DeForest Buckner from IRD.) |
| | CB | Activated (The Indianapolis Colts elevated CB Kelvin Joseph to the active roster from the practice squad.) |
| | RB | Waived (The Indianapolis Colts waived RB Evan Hull.) |
| | LB | Activated (The Indianapolis Colts activated LB Cameron McGrone from IRD.) |
| | K | Released (The Indianapolis Colts released K Spencer Shrader.) |
| | WR | Pract. squad add (The Indianapolis Colts signed WR Ethan Fernea to the practice squad.) |
| | DT | Placed on Injured Reserve, Designated for Return (The Indianapolis Colts placed DT DeForest Buckner on IRD.) |
| | CB | Pract. squad add (The Indianapolis Colts assigned CB Kelvin Joseph to the practice squad.) |
| | K | Pract. squad add (The Indianapolis Colts signed K Spencer Shrader to the practice squad.) |
| | RB | Released (The Indianapolis Colts released RB Trent Pennix.) |
| | LB | Pract. squad add (The Indianapolis Colts assigned LB Liam Anderson to the practice squad.) |
| | LB | Pract. squad add (The Indianapolis Colts signed LB Austin Ajiake to the practice squad.) |
| | CB | Activated (The Indianapolis Colts elevated CB Kelvin Joseph to the active roster from the practice squad.) |
| | LB | Activated (The Indianapolis Colts elevated LB Liam Anderson to the active roster from the practice squad.) |
| | WR | Released (The Indianapolis Colts released WR Ethan Fernea.) |
| | LB | Released (The Indianapolis Colts released LB Austin Ajiake.) |
| | WR | Pract. squad add (The Indianapolis Colts signed WR Ethan Fernea to the practice squad.) |
| | K | Released (The Indianapolis Colts released K Spencer Shrader.) |
| | RB | Pract. squad add (The Indianapolis Colts signed RB Salvon Ahmed to the practice squad.) |
| | K | Pract. squad add (The Indianapolis Colts signed K Spencer Shrader to the practice squad.) |
| | RB | Signed (The Indianapolis Colts signed RB Evan Hull to the active roster from the practice squad.) |
| | T | Pract. squad add (The Indianapolis Colts signed T Jack Wilson to the practice squad.) |
| | K | Released (The Indianapolis Colts released K Spencer Shrader.) |
| | RB | Pract. squad add (The Indianapolis Colts signed RB Trent Pennix to the practice squad.) |
| | CB | Signed (The Indianapolis Colts signed CB David Long to the active roster from the practice squad.) |
| | RB | Pract. squad add (The Indianapolis Colts assigned RB Evan Hull to the practice squad.) |
| | CB | Pract. squad add (The Indianapolis Colts assigned CB David Long to the practice squad.) |
| | CB | Waived (The Indianapolis Colts waived CB Dallis Flowers.) |
| | G | Placed on Injured Reserve (The Indianapolis Colts placed G Will Fries on IR.) |
| | CB | Released (The Indianapolis Colts released CB Gregory Junior.) |
| | K | Pract. squad add (The Indianapolis Colts signed K Spencer Shrader to the practice squad.) |
| | CB | Activated (The Indianapolis Colts elevated CB David Long to the active roster from the practice squad.) |
| | RB | Activated (The Indianapolis Colts elevated RB Evan Hull to the active roster from the practice squad.) |
| | RB | Released (The Indianapolis Colts released RB Trent Pennix.) |
| | CB | Pract. squad add (The Indianapolis Colts signed CB Alex Johnson to the practice squad.) |
| | DT | Signed (The Indianapolis Colts signed DT Adam Gotsis to the active roster from the practice squad.) |
| | DE | Placed on Injured Reserve (The Indianapolis Colts placed DE Tyquan Lewis on IR.) |
| | RB | Pract. squad add (The Indianapolis Colts signed RB Trent Pennix to the practice squad.) |
| | K | Released (The Indianapolis Colts released K Spencer Shrader.) |
| | CB | Pract. squad add (The Indianapolis Colts signed CB Kelvin Joseph to the practice squad.) |
| | CB | Pract. squad add (The Indianapolis Colts assigned CB David Long to the practice squad.) |
| | DT | Pract. squad add (The Indianapolis Colts assigned DT Adam Gotsis to the practice squad.) |
| | CB | Activated (The Indianapolis Colts elevated CB David Long Jr. to the active roster from the practice squad.) |
| | DT | Activated (The Indianapolis Colts elevated DT Adam Gotsis to the active roster from the practice squad.) |
| | DT | Pract. squad add (The Indianapolis Colts signed DT Josiah Bronson to the practice squad.) |
| | DE | Pract. squad add (The Indianapolis Colts signed DE Derek Rivers to the practice squad.) |
| | QB | Placed on Injured Reserve (The Indianapolis Colts placed QB Jason Bean on practice squad IR.) |
| | CB | Released (The Indianapolis Colts released CB Kelvin Joseph.) |
| | DE | Pract. squad add (The Indianapolis Colts signed DE Titus Leo to the practice squad.) |
| | DT | Placed on Injured Reserve (The Indianapolis Colts placed DT DeForest Buckner on IR.) |
| | CB | Released (The Indianapolis Colts released CB Ameer Speed.) |
| | CB | Pract. squad add (The Indianapolis Colts signed CB Gregory Junior to the practice squad.) |
| | DE | Activated (The Indianapolis Colts elevated DE Genard Avery to the active roster from the practice squad.) |
| | DT | Pract. squad add (The Indianapolis Colts signed DT Adam Gotsis to the practice squad.) |
| | DT | Released (The Indianapolis Colts released DT McTelvin Agim.) |
| | DE | Activated (The Indianapolis Colts elevated DE Genard Avery to the active roster from the practice squad.) |
| | S | Activated (The Indianapolis Colts elevated SAF Ronnie Harrison Jr. to the active roster from the practice squad.) |
| | DE | Released (The Indianapolis Colts released DE Titus Leo.) |
| | CB | Pract. squad add (The Indianapolis Colts signed CB Kelvin Joseph to the practice squad.) |
| | S | Pract. squad add (The Indianapolis Colts signed S Ronnie Harrison Jr. to the practice squad.) |
| | CB | Placed on Injured Reserve (The Indianapolis Colts placed CB JuJu Brents on IR.) |
| | CB | Activated (The Indianapolis Colts elevated CB Chris Lammons to the active roster from the practice squad.) |
| | K | Activated (The Indianapolis Colts elevated K Spencer Shrader to the active roster from the practice squad.) |
| | CB | Signed (The Indianapolis Colts signed CB David Long Jr. to the practice squad.) |
| | G | Pract. squad add (The Indianapolis Colts signed G Atonio Mafi to the practice squad.) |
| | DE | Pract. squad add (The Indianapolis Colts signed DE Titus Leo to the practice squad.) |
| | K | Pract. squad add (The Indianapolis Colts signed K Spencer Shrader to the practice squad.) |
| | TE | Pract. squad add (The Indianapolis Colts signed TE Sean McKeon to the practice squad.) |
| | DT | Pract. squad add (The Indianapolis Colts signed DT McTelvin Agim to the practice squad.) |
| | CB | Claimed (The Tennessee Titans claimed CB Darrell Baker Jr. off waivers.) To |
| | S | Signed (The Indianapolis Colts signed S Marcel Dabo to the practice squad.) |
| | CB | Claimed (The Indianapolis Colts claimed CB Samuel Womack III off waivers.) From |
| | LB | Pract. squad add (The Indianapolis Colts signed LB Austin Ajiake to the practice squad.) |
| | DE | Signed (The Indianapolis Colts signed DE Genard Avery to the practice squad.) |
| | CB | Signed (The Indianapolis Colts signed CB Ameer Speed to the practice squad.) |
| | CB | Waived (The Indianapolis Colts waived CB Darrell Baker Jr.) |
| | WR | Signed (The Indianapolis Colts signed WR D.J. Montgomery to the practice squad.) |
| | RB | Pract. squad add (The Indianapolis Colts signed RB Evan Hull to the practice squad.) |
| | CB | Signed (The Indianapolis Colts signed CB Jaylin Simpson to the practice squad.) |
| | QB | Signed (The Indianapolis Colts signed QB Jason Bean to the practice squad.) |
| | LB | Signed (The Indianapolis Colts signed LB Liam Anderson to the practice squad.) |
| | WR | Signed (The Indianapolis Colts signed WR Laquon Treadwell to the practice squad.) |
| | CB | Signed (The Indianapolis Colts signed CB Chris Lammons to the practice squad.) |
| | DT | Claimed (The Las Vegas Raiders claimed DT Jonah Laulu off waivers.) To |
| | DT | Claimed (The New England Patriots claimed DT Eric Johnson II off waivers.) To |
| | WR | Placed on Injured Reserve (The Indianapolis Colts placed WR Juwann Winfree on injured reserve.) |
| | LB | Placed on Injured Reserve, Designated for Return (The Indianapolis Colts placed LB Cameron McGrone on the IRD list.) |
| | TE | Waived (The Indianapolis Colts waived TE Jordan Murray.) |
| | CB | Released (The Indianapolis Colts released CB Chris Lammons.) |
| | DT | Waived (The Indianapolis Colts waived DT Jonah Laulu.) |
| | LB | Waived (The Indianapolis Colts waived LB Liam Anderson.) |
| | WR | Released (The Indianapolis Colts released WR D.J. Montgomery.) |
| | DE | Released (The Indianapolis Colts released DE Genard Avery.) |
| | CB | Waived (The Indianapolis Colts waived CB Ameer Speed.) |
| | C | Waived (The Indianapolis Colts waived C Mike Panasiuk.) |
| | TE | Released (The Indianapolis Colts released TE Eric Tomlinson.) |
| | QB | Waived (The Indianapolis Colts waived QB Jason Bean.) |
| | WR | Released (The Indianapolis Colts released WR Laquon Treadwell.) |
| | S | Waived (The Indianapolis Colts waived SAF Michael Tutsie.) |
| | RB | Waived (The Indianapolis Colts waived RB Zavier Scott.) |
| | DE | Waived (The Indianapolis Colts waived DE Titus Leo.) |
| | TE | Placed on Injured Reserve (The Indianapolis Colts placed TE Jelani Woods on IR.) |
| | S | Waived (The Indianapolis Colts waived SAF Marcel Dabo.) |
| | RB | Waived (The Indianapolis Colts waived RB Evan Hull.) |
| | G | Waived (The Indianapolis Colts waived G Arlington Hambright.) |
| | T | Waived (The Indianapolis Colts waived T Jake Witt.) |
| | RB | Waived (The Indianapolis Colts waived RB Demetric Felton.) |
| | DE | Placed on Injured Reserve, Designated for Return (The Indianapolis Colts placed DE Samson Ebukam on the IRD list.) |
| | CB | Waived (The Indianapolis Colts waived CB Micah Abraham.) |
| | LB | Waived (The Indianapolis Colts waived LB Austin Ajiake.) |
| | DT | Waived (The Indianapolis Colts waived DT Eric Johnson II.) |
| | LB | Waived (The Indianapolis Colts waived LB Craig Young.) |
| | CB | Waived (The Indianapolis Colts waived CB Jaylin Simpson.) |
| | DE | Released (The Indianapolis Colts released DE Levi Bell.) |
| | WR | Released (The Indianapolis Colts released WR Greg Ward.) |
| | DE | Released (The Indianapolis Colts released DE Derek Rivers.) |
| | S | Released (The Indianapolis Colts released S Ronnie Harrison Jr.) |
| | LB | Waived (The Indianapolis Colts waived LB Mike Smith Jr.) |
| | WR | Waived (The Indianapolis Colts waived WR Derek Slywka.) |
| | QB | Waived (The Indianapolis Colts waived QB Kedon Slovis.) |
| | K | Waived (The Indianapolis Colts waived K Spencer Shrader.) |
| | CB | Waived (The Indianapolis Colts waived CB Clay Fields III.) |
| | WR | Released (The Indianapolis Colts released WR Tyrie Cleveland.) |
| | G | Waived Injury (The Indianapolis Colts waived G Josh Sills due to injury.) |
| | WR | Waived Injury (The Indianapolis Colts waived WR Ethan Fernea due to injury.) |
| | G | Placed on Injured Reserve (The Indianapolis Colts placed G Josh Sills on IR after being waived due to injury.) |
| | DT | Activated (The Indianapolis Colts activated DT Raekwon Davis from the non-football injury list.) |
| | G | Waived Injury (The Indianapolis Colts waived G Josh Sills due to injury.) |
| | C | Signed (The Indianapolis Colts signed DT Mike Panasiuk.) |
| | C | Placed on Injured Reserve (The Indianapolis Colts placed C Ryan Coll on IR.) |
| | LB | Signed (The Indianapolis Colts signed LB Mike Smith Jr.) |
| | WR | Placed on Injured Reserve (The Indianapolis Colts placed WR Ethan Fernea on IR after being waived due to injury.) |
| | S | Waived (The Indianapolis Colts waived S Kendell Brooks.) |
| | WR | Signed (The Indianapolis Colts signed WR Greg Ward.) |
| | DE | Signed (The Indianapolis Colts signed DE Derek Rivers.) |
| | WR | Waived Injury (The Indianapolis Colts waived WR Ethan Fernea due to injury.) |
| | RB | Waived Injury (The Indianapolis Colts waived RB Trent Pennix due to injury.) |
| | RB | Claimed (The Indianapolis Colts claimed RB Demetric Felton off waivers.) From |
| | C | Placed on Injured Reserve (The Indianapolis Colts placed C Wesley French on IR.) |
| | C | Signed (The Indianapolis Colts signed OT Ryan Coll.) |
| | CB | Activated (The Indianapolis Colts activated CB Chris Lammons from the PUP list.) |
| | OL | Waived (The Indianapolis Colts waived G Lewis Kidd.) |
| | DE | Signed (The Indianapolis Colts signed DE Levi Bell.) |
| | WR | Waived (The Indianapolis Colts waived WR Xavier White.) |
| | WR | Signed (The Indianapolis Colts signed WR Laquon Treadwell.) |
| | DT | Reserve/non football injury (The Indianapolis Colts placed DT Raekwon Davis on the Non-football injury lsit.) |
| | CB | Placed on PUPL (The Indianapolis Colts placed CB Chris Lammons on the PUP list.) |
| | G | Claimed (The Jacksonville Jaguars claimed OL Jack Anderson off waivers.) To |
| | WR | Signed (The Indianapolis Colts signed WR Derek Slywka.) |
| | G | Released (The Indianapolis Colts released OL Jack Anderson.) |
| | S | Placed on Injured Reserve (The Indianapolis Colts placed S Daniel Scott on IR.) |
| | CB | Signed (The Indianapolis Colts signed CB Clay Fields III.) |
| | WR | Signed (The Indianapolis Colts signed WR Adonai Mitchell.) |
| | WR | Signed (The Indianapolis Colts signed WR Adonai Mitchell.) |
| | WR | Signed (The Indianapolis Colts signed WR Anthony Gould.) |
| | T | Signed (The Indianapolis Colts signed OT Matt Goncalvez.) |
| | G | Signed (The Indianapolis Colts signed OG Tanor Bortolini.) |
| | DT | Signed (The Indianapolis Colts signed DT Jonah Laulu.) |
| | CB | Signed (The Indianapolis Colts signed CB Micah Abraham.) |
| | WR | Waived (The Indianapolis Colts waived WR Terrell Bynum.) |
| | CB | Signed (The Indianapolis Colts signed CB Jaylin Simpson.) |
| | LB | Signed (The Indianapolis Colts signed LB Jaylon Carlies.) |
| | DE | Signed (The Indianapolis Colts signed DE Laiatu Latu.) |
| | OL | Signed (The Indianapolis Colts signed OL Daniel Johnson.) |
| | OL | Signed (The Indianapolis Colts signed OL Aidan Hemphill.) |
| | WR | Signed (The Indianapolis Colts signed WR Dakota Caton.) |
| | DB | Signed (The Indianapolis Colts signed DB Brandon Bishop.) |
| | OT | Signed (The Indianapolis Colts signed OT Jake Hornibrook.) |
| | OL | Signed (The Indianapolis Colts signed OL Ben Farrell.) |
| | OL | Signed (The Indianapolis Colts signed OL Jake Kradel.) |
| | WR | Signed (The Indianapolis Colts signed WR Kaylon Horton.) |
| | DB | Signed (The Indianapolis Colts signed DB Devlin Kirklin.) |
| | S | Signed (The Indianapolis Colts signed S Julian Blackmon.) |
| | S | Declared Free Agent (S Julian Blackmon elected free agency.) |
| | DL | Declared Free Agent (DE Jake Martin elected free agency.) |
| | RB | Re-signed (The Indianapolis Colts re-signed RB Trey Sermon.) |
| | QB | Signed (The Indianapolis Colts signed QB Joe Flacco.) |
| | RB | Contract Expired (The Indianapolis Colts did not tender to a contract to RB Trey Sermon.) |
| | DT | Signed (The Indianapolis Colts signed DT Raekwon Davis.) |
| | RB | Declared Free Agent (RB Zack Moss elected free agency.) |
| | WR | Declared Free Agent (WR Isaiah McKenzie elected free agency.) |
| | QB | Declared Free Agent (QB Gardner Minshew elected free agency.) |