| | RB | Waived (The Buffalo Bills waived RB Isaiah Bowser.) |
| | LB | Signed (The Buffalo Bills signed DE Leonard Floyd.) |
| | DT | Released (The Buffalo Bills released DT Brandin Bryant.) |
| | WR | Signed (The Buffalo Bills signed WR Marcell Ateman.) |
| | WR | Released (The Buffalo Bills released WR Braydon Johnson.) |
| | OL | Signed (The Buffalo Bills signed OL Brandon Shell.) |
| | TE | Signed (The Buffalo Bills signed TE Joel Wilson.) From |
| | FS | Signed (The Buffalo Bills signed S Dean Marlowe.) |
| | RB | Signed (The Buffalo Bills signed RB Isaiah Bowser.) |
| | LB | Signed (The Buffalo Bills signed LB Shane Ray.) |
| | LB | Signed (The Buffalo Bills signed LB Travin Howard. ) |
| | DT | Signed (The Buffalo Bill signed DT DJ Dale.) |
| | WR | Signed (The Buffalo Bills signed WR Isaiah Coulter.) |
| | RB | Signed (The Buffalo Bills signed WR Jordan Mims.) |
| | WR | Signed (The Buffalo Bills signed WR Tyrell Shavers.) |
| | T | Signed (The Buffalo Bills signed OL Richard Gouraige.) |
| | WR | Signed (The Buffalo Bills signed WR Jalen Wayne.) |
| | OL | Signed (The Buffalo Bills signed OL Noah Henderson.) |
| | DT | Claimed (The Buffalo Bills claimed DE Kameron Cline off waivers.) |
| | DT | Signed (The Buffalo Bills signed DL Poona Ford.) |
| | RB | Signed (The Buffalo Bills signed RB Latavius Murray.) |
| | LB | Re-signed (The Buffalo Bills re-signed LB A.J. Klein.) |
| | OL | Signed (The Buffalo Bills signed OG Kevin Jarvis.) |
| | DE | Re-signed (The Buffalo Bills re-signed DL Shaq Lawson.) |
| | DT | Re-signed (The Buffalo Bills re-signed DL Jordan Phillips.) |
| | S | Signed (The Buffalo Bills signed DB Taylor Rapp.) |
| | G | Signed (The Buffalo Bills signed OL David Edwards.) |
| | OL | Re-signed (The Buffalo Bills re-signed OL David Quessenberry.) |
| | RB | Signed (The Buffalo Bills signed RB Damien Harris.) |
| | WR | Signed (The Buffalo Bills signed WR Trent Sherfield.) |
| | WR | Released (The Buffalo Bills released WR Isaiah McKenzie.) |
| | S | Re-signed (The Buffalo Bills re-signed DB Jordan Poyer.) |
| | QB | Signed (The Buffalo Bills signed QB Kyle Allen.) |
| | WR | Signed (The Buffalo Bills signed WR Deonte Harty.) |
| | G | Signed (The Buffalo Bills signed OL Connor McGovern.) |
| | TE | Declared Free Agent (TE Tommy Sweeney declared free agency.) |
| | LB | Declared Free Agent (LB Tremaine Edmunds declared free agency.) |
| | G | Declared Free Agent (OG Connor McGovern declared free agency.) |
| | OL | Declared Free Agent (OL David Quessenberry declared free agency.) |
| | DT | Declared Free Agent (DT Jordan Phillips declared free agency.) |
| | G | Declared Free Agent (OG Greg Van Roten declared free agency.) |
| | WR | Declared Free Agent (WR Jamison Crowder declared free agency.) |
| | G | Declared Free Agent (OG Rodger Saffold declared free agency.) |
| | S | Declared Free Agent (S Jaquan Johnson declared free agency.) |
| | RB | Declared Free Agent (RB Devin Singletary declared free agency.) |
| | QB | Declared Free Agent (QB Case Keenum declared free agency.) |
| | RB | Declared Free Agent (RB Taiwan Jones declared free agency.) |
| | FS | Declared Free Agent (FS Dean Marlowe declared free agency.) |
| | WR | Declared Free Agent (WR Jake Kumerow declared free agency.) |
| | S | Declared Free Agent (S Jordan Poyer declared free agency.) |
| | LB | Declared Free Agent (LB A.J. Klein declared free agency.) |
| | T | Declared Free Agent (OL Bobby Hart declared free agency.) |
| | DE | Declared Free Agent (DE Shaq Lawson declared free agency.) |
| | S | Signed (The Buffalo Bills signed SAF Zayne Anderson from the Kansas City Chiefs' practice squad.) From |
| | WR | Released (The Buffalo Bills released WR John Brown.) |
| | OL | Released (The Buffalo Bills released OL Justin Murray.) |
| | DE | Released (The Buffalo Bills released DL Mike Love.) |
| | RB | Released (The Buffalo Bills released RB Duke Johnson.) |
| | WR | Signed (The Buffalo Bills signed WR Dezmon Patmon to a reserve/future contract.) |
| | T | Signed (The Buffalo Bills signed T Alec Anderson to a reserve/future contract.) |
| | CB | Signed (The Buffalo Bills signed CB Kyler McMichael to a reserve/future contract.) |
| | T | Signed (The Buffalo Bills signed T Ryan Van Demark to a reserve/future contract.) |
| | OL | Signed (The Buffalo Bills signed C Greg Mancz to a reserve/future contract.) |
| | DE | Signed (The Buffalo Bills signed DE Kinglsey Jonathan to a reserve/future contract.) |
| | WR | Signed (The Buffalo Bills signed WR Kee'Sean Johnson to a reserve/future contract.) |
| | CB | Signed (The Buffalo Bills signed CB Ja'Marcus Ingram to a reserve/future contract.) |
| | TE | Signed (The Buffalo Bills signed TE Zach Davidson to a reserve/future contract.) |
| | DT | Signed (The Buffalo Bills signed DT Brandin Bryant to a reserve/future contract.) |
| | DT | Signed (The Buffalo Bills signed DT Cortez Broughton to a reserve/future contract.) |
| | QB | Signed (The Buffalo Bills signed QB Matt Barkley to a reserve/future contract.) |
| | DT | Signed (The Buffalo Bills signed DT Eli Ankou to a reserve/future contract.) |
| | OL | Signed (The Buffalo Bills signed OT Justin Murray to the practice squad) |
| | T | Placed on Injured Reserve (The Buffalo Bills placed OL Alec Anderson on IR.) |
| | OL | Signed (The Buffalo Bills signed OL Greg Mancz to the practice squad.) |
| | WR | Signed (The Buffalo Bills signed WR Dezmon Patmon to the practice squad.) |
| | DT | Signed (The Buffalo Bills signed DL Cortez Broughton to the practice squad.) |
| | LB | Released (The Buffalo Bills released LB Joe Giles-Harris.) |
| | WR | Released (The Buffalo Bills released WR Tanner Gentry.) |
| | DT | Released (The Buffalo Bills released DT Cortez Broughton from the practice squad. ) |
| | DT | Activated (The Buffalo Bills elevated DT Eli Ankou to the active roster. ) |
| | WR | Activated (The Buffalo Bills elevated WR John Brown to the active roster. ) |
| | OL | Signed (The Buffalo Bills signed T Justin Murray to the practice squad. ) |
| | OL | Released (The Buffalo Bills released OL Justin Murray.) |
| | WR | Activated (The Buffalo Bills elevated WR Cole Beasley to the active roster.) |
| | DT | Pract. squad add (The Buffalo Bills assigned DL Eli Ankou to the practice squad.) |
| | WR | Placed on Injured Reserve, Designated for Return (The Buffalo Bills placed WR Jamison Crowder on IRD.) |
| | S | Placed on Injured Reserve, Designated for Return (The Buffalo Bills placed DB Micah Hyde on IRD.) |
| | WR | Pract. squad add (The Buffalo Bills assigned WR John Brown to the practice squad.) |
| | WR | Activated (The Buffalo Bills elevated WR John Brown from the practice squad. ) |
| | S | Placed on Injured Reserve (The Buffalo Bills placed SAF Damar Hamlin on injured reserve.) |
| | CB | Activated (The Buffalo Bills activated CB Christian Benford from injured reserve.) |
| | CB | Released (The Buffalo Bills released DB Xavier Rhodes.) |
| | S | Signed (The Buffalo Bills signed DB Jared Mayden. ) From |
| | T | Activated (The Buffalo Bills elevated OL Alec Anderson to the active roster.) |
| | WR | Activated (The Buffalo Bills elevated WR Cole Beasley to the active roster.) |
| | CB | Placed on Injured Reserve, Designated for Return (The Buffalo Bills placed CB Christian Benford on the IRD list.) |
| | DE | Activated (The Buffalo Bills activated DE Kingsley Jonathan from Practice Squad.) |
| | WR | Activated (The Buffalo Bills have activated WR Cole Beasley from Practice Squad.) |
| | DT | Released (The Buffalo Bills released DL Kendal Vickers.) |
| | DT | Signed (The Buffalo Bills signed DL Brandin Bryant to the practice squad.) |
| | DT | Released (The Buffalo Bills released DL Brandin Bryant.) |
| | G | Activated (The Buffalo Bills activated OL Ike Boettger from IRD.) |
| | WR | Activated (The Buffalo Bills elevated WR Cole Beasley from the practice squad.) |
| | DT | Signed (The Buffalo Bills signed DL Brandin Bryant.) |
| | WR | Signed (The Buffalo Bills signed WR Cole Beasley to the practice squad.) |
| | WR | Released (The Buffalo Bills released WR Marquez Stevenson.) |
| | DL | Released (The Buffalo Bills released DL C.J. Brewer.) |
| | WR | Pract. squad add (The Buffalo Bills assigned WR John Brown to the practice squad.) |
| | WR | Activated (The Buffalo Bills elevated WR John Brown from the practice squad. ) |
| | WR | Released (The Buffalo Bills released WR Isaiah Coulter.) |
| | WR | Signed (The Buffalo Bills signed WR Marquez Stevenson to the practice squad.) |
| | DT | Placed on Injured Reserve (The Buffalo Bills placed DL Eli Ankou on IR.) |
| | DT | Signed (The Buffalo Bills signed DL Kendal Vickers to the practice squad.) |
| | DL | Signed (The Buffalo Bills signed DT C.J. Brewer off the practice squad.) |
| | WR | Released (The Buffalo Bills released WR Marquez Stevenson.) |
| | DT | Signed (The Buffalo Bills signed DT Cortex Broughton to the practice squad.) |
| | WR | Pract. squad add (The Buffalo Bills assigned WR John Brown to the practice squad.) |
| | WR | Activated (The Buffalo Bills elevated WR John Brown from the practice squad. ) |
| | LB | Placed on Injured Reserve (The Buffalo Bills placed LB Von Miller on IR.) |
| | WR | Pract. squad add (Signed) From |
| | DL | Pract. squad add (Signed) |
| | CB | Active/prac. squad (Signed) |
| | DE | Pract. squad add (Signed) |
| | WR | Pract. squad add (Signed) |
| | DT | Active/prac. squad (Signed) To |
| | WR | Active/prac. squad (Signed) |
| | DE | Active/prac. squad (Signed) |
| | OL | Signed (Signed) To |
| | CB | Pract. squad add (Signed) |
| | WR | Pract. squad add (Signed) |
| | CB | Active/prac. squad (Signed) |
| | WR | Active/prac. squad (Signed) |
| | LB | Acquired from waiver (Signed) From |
| | OL | Pract. squad del (Signed) |
| | DE | Pract. squad add (Signed) From |
| | DT | Pract. squad add (Signed) To |
| | LB | Pract. squad add (Signed) To |
| | CB | Pract. squad add (Signed) |
| | RB | Pract. squad add (Signed) |
| | CB | Active/prac. squad (Signed) |
| | RB | Active/prac. squad (Signed) |
| | DT | Pract. squad add (Signed) To |
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