| Player | Sacks |
|---|---|
| Bruce Smith | 200.0 |
| Reggie White | 198.0 |
| Kevin Greene | 160.0 |
Julius Peppers* | 157.0 |
| Chris Doleman | 150.5 |
| Michael Strahan | 141.5 |
| Jason Taylor | 139.5 |
| DeMarcus Ware | 139.0 |
| John Randle | 137.5 |
| Richard Dent | 137.5 |
| Jared Allen | 136.0 |
| John Abraham | 133.5 |
| Leslie O'Neal | 132.5 |
| Lawrence Taylor | 132.5 |
Terrell Suggs* | 131.0 |
| Rickey Jackson | 128.0 |
| Derrick Thomas | 126.5 |
| Dwight Freeney | 125.5 |
| Robert Mathis | 123.0 |
| Simeon Rice | 122.0 |
| Clyde Simmons | 121.5 |
| Sean Jones | 113.0 |
| Greg Townsend | 109.5 |
| Pat Swilling | 107.5 |
| Trace Armstrong | 106.0 |
| Elvis Dumervil | 105.0 |
| Neil Smith | 104.5 |
| Kevin Carter | 104.5 |
| Jim Jeffcoat | 102.5 |
| William Fuller | 100.5 |
| Charles Haley | 100.5 |
| Andre Tippett | 100.0 |
| Mario Williams | 98.0 |
| Joey Porter | 98.0 |
| Jacob Green | 97.5 |
| Dexter Manley | 97.5 |
| Simon Fletcher | 97.5 |
| Warren Sapp | 96.5 |
| Robert Porcher | 95.5 |
| Steve McMichael | 95.0 |
| Henry Thomas | 93.5 |
Cameron Wake* | 93.0 |
| Trevor Pryce | 91.0 |
Von Miller* | 91.0 |
| Trent Cole | 90.5 |
| Tamba Hali | 90.0 |
| Bryant Young | 89.5 |
| Ken Harvey | 89.0 |
| Leonard Little | 87.5 |
| Justin Smith | 87.5 |
| Willie McGinest | 86.0 |
| Osi Umenyiora | 85.5 |
| James Harrison | 85.0 |
| Howie Long | 84.0 |
| Greg Ellis | 84.0 |
| Leonard Marshall | 83.5 |
| La'Roi Glover | 83.5 |
J.J. Watt* | 83.0 |
| Charles Mann | 83.0 |
| Wayne Martin | 82.5 |
| Lee Williams | 82.5 |
| Patrick Kerney | 82.5 |
Clay Matthews* | 82.0 |
| Shaun Phillips | 81.5 |
| Tim Harris | 81.0 |
| Andre Carter | 81.0 |
| Hugh Douglas | 80.0 |
| Jason Gildon | 80.0 |
| Chad Brown | 79.0 |
| Karl Mecklenburg | 79.0 |
| Aaron Schobel | 78.0 |
| Ray Childress | 76.5 |
| Bryce Paup | 75.0 |
Calais Campbell* | 75.0 |
Ryan Kerrigan* | 74.5 |
| Kabeer Gbaja-Biamila | 74.5 |
| Cliff Avril | 74.5 |
| Shaun Ellis | 74.0 |
| Jevon Kearse | 74.0 |
| Michael Sinclair | 73.5 |
| Rob Burnett | 73.0 |
Justin Houston* | 72.5 |
| Lance Johnstone | 72.0 |
| Cornelius Bennett | 71.5 |
| Michael McCrary | 71.0 |
Chandler Jones* | 70.5 |
| Peter Boulware | 70.0 |
Carlos Dunlap* | 70.0 |
| Clay Matthews | 69.5 |
| Chris Clemons | 69.0 |
| Charles Johnson | 68.0 |
| Will Smith | 68.0 |
| Freddie Joe Nunn | 67.5 |
| Adewale Ogunleye | 67.0 |
| Darren Howard | 67.0 |
Geno Atkins* | 67.0 |
| Justin Tuck | 67.0 |
| Al Baker | 65.5 |
| Marco Coleman | 65.5 |
| Jason Babin | 65.0 |