Murray returned from a month on the sidelines with an ankle injury to throw for two touchdowns and run in two more.
The AFC East lead is on the line when Josh Allen and the Bills host Mac Jones and the Patriots. Allen passed for four touchdowns to lead Buffalo to a 31-6 victory at New Orleans on Thanksgiving, but the Bills (7-4) have split their last six games overall. The Patriots (8-4) have won six in a row since a 35-29 overtime loss to Dallas on Oct. 17.
Tampa Bay is now one game closer to having Brown return from a suspension that absolutely would have cost a lesser player his roster spot.