New York Giants at San Francisco 49ers: Predictions, picks and odds for NFL Week 3 game

The San Francisco 49ers (2-0) finally have their home opener as they host the New York Giants (1-1) to open up Week 3 on Thursday night at Levi's Stadium.

Brock Purdy has been flying high with the offense, assisted by Christian McCaffrey. Brandon Aiyuk had a stellar Week 1, but was shaken up last week and might miss this matchup with a shoulder injury. Nick Bosa and the defense held the Pittsburgh Steelers to 7 points in the season opener.

To start their season, Daniel Jones and company went six quarters without scoring but came from behind to defeat the Arizona Cardinals last week. Running back Saquon Barkley sprained his ankle in the game and is expected to be out three weeks.

The last time the Giants and 49ers played was in 2020 when San Francisco won 36-9 behind backup quarterback Nick Mullens. Aiyuk had a touchdown on the day.

Will the 49ers be able to continue their dominance?

PROP TALK: These are the best prop bets for NFL games this week

49ers vs. Giants odds, moneyline, over/under

The 49ers are favorites to defeat the Giants, according to the BetMGM NFL odds. Looking to wager? Check out the best mobile sports betting apps offering NFL betting promos in 2023.

  • Spread: 49ers (-10.5)

  • Moneyline: 49ers (-600); Giants (+425)

  • Over/under: 43.5

Not interested in this game? Our guide to the NFL betting odds, picks and spreads has you covered with Thursday Night Football odds, Sunday Night Football odds and/or Monday Night Football odds.

If you’re new to sports betting, don’t worry. We have tips for beginners on how to place bet online. And USA TODAY readers can claim exclusive promos and bonus codes with the online sportsbooks and sports betting sites.

Which NFL teams can survive 0-2 start? Ranking all nine by playoff viability

Brandon Aiyuk had a touchdown last time the 49ers met the Giants in 2020. He might not play in their 2023 Week 3 matchup after he suffered a shoulder injury.
Brandon Aiyuk had a touchdown last time the 49ers met the Giants in 2020. He might not play in their 2023 Week 3 matchup after he suffered a shoulder injury.

NFL Week 3 odds, predictions and picks

49ers vs. Giants | Ravens vs. Colts | Browns vs. Titans | Lions vs. Falcons | Packers vs. Saints | Jaguars vs. Texans | Dolphins vs. Broncos | Vikings vs. Chargers | Jets vs. Patriots | Commanders vs. Bills | Seahawks vs. Panthers | Cardinals vs. Cowboys | Chiefs vs. Bears | Raiders vs. Steelers | Buccaneers vs. Eagles | Bengals vs. Rams

Lorenzo Reyes: 49ers 27, Giants 13

Short week and a West Coast trip, New York’s offensive line is a mess and the Giants will be without Saquon Barkley. The Niners are explosive pretty much everywhere. Nick Bosa is going to have a field day.

Tyler Dragon: 49ers 28, Giants 10

The 49ers are the best team in the NFL after two weeks. Brock Purdy is managing the game and getting the football to San Francisco’s explosive playmakers. The 49ers’ defense is once again stout with linebacker Fred Warner and defensive end Nick Bosa leading the way. The Giants will be without Saquon Barkley (ankle), which means it’s going to be a long night for New York.

Victoria Hernandez: 49ers 32, Giants 13

The Giants have good momentum after scoring all 31 points in the second half during their come-from-behind win last week but will struggle again without Saquon Barkley. The 49ers are simply the better team all around.

Jordan Mendoza: 49ers 30, Giants 12

The Giants were able to pull off a miraculous comeback in Week 2, but that was against the lowly Arizona Cardinals. Falling behind the 49ers is not something they’ll be able to overcome – especially without Saquon Barkley – as San Francisco cruises to an easy win.

NFL power rankings Week 3: Saints, Steelers tick up after 'Monday Night Football' wins

NFL salaries: These are the highest paid NFL players

Gannett may earn revenue from sports betting operators for audience referrals to betting services. Sports betting operators have no influence over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. Terms apply, see operator site for Terms and Conditions. If you or someone you know has a gambling problem, help is available. Call the National Council on Problem Gambling 24/7 at 1-800-GAMBLER (NJ, OH), 1-800-522-4700 (CO), 1-800-BETS-OFF (IA), 1-800-9-WITH-IT (IN). Must be 21 or older to gamble. Sports betting and gambling are not legal in all locations. Be sure to comply with laws applicable where you reside.

This article originally appeared on USA TODAY: New York Giants at San Francisco 49ers: Game predictions, picks, odds