South Carolina opens its second week of SEC play as the betting favorites against Mississippi State.

USC is a 4.5-point favorite, according to FanDuel and DraftKings opening odds. Circa Sports lists the Gamecocks as 4-point favorites.

The over/under is 52.5 points, according to FanDuel.

Both teams are coming off ranked losses to open SEC play. The Gamecocks (1-2, 0-1 SEC) fell to No. 1 Georgia, 24-14 in Athens, while the other Bulldogs (2-1, 0-1 SEC) fell to No. 14 LSU, 41-14 in Starkville.

South Carolina is 2-1 against the spread so far this season, after starting to season 0-1 during the loss to UNC in Week 1. Mississippi State is 1-2 against the spread.

This marks the first time since 2016 the two programs faced off, and the first since 2013 they’ve played at Williams-Brice Stadium. The Gamecocks lost the last meeting, 27-14. USC leads all all-time series 9-7-0.