Mesoraco singled in the seventh and moved to second on a wild pitch. He took off from second base on Billy Hamilton's double and fell to the ground with a strained left hamstring after rounding third base. He struggled back to his feet and limped across the plate before slowly leaving the field.
The Reds said Frazier was pulled from the game due to tightness in his left leg in the fifth inning. He may have injured his leg sliding into second base on a double in the second inning.
Neftali Soto replaced Frazier. Brayan Pena replaced Mesoraco.