City were 3-0 winners over the Greek side in the reverse fixture earlier this month, with Gabriel Jesus, Ferran Torres and Joao Cancelo getting on the scoresheet for the hosts.
With the Premier League club faultless in the tournament so far this season, they will be fairly confident of replicating their last result against Pedro Martins’ side and moving to 12 points from 12 in Group C – effectively sealing their place in the last 16.
Here’s everything you need to know about the Champions League fixture.
When is it?
The match kicks off at 17:55 BST on Wednesday 25 November.
How can I watch it?
The game will air live on BT Sport. Subscribers can also stream it on the BT Sport website and app.
Olympiacos: Jose Sa; Drager, Semedo, Cisse, Rafinha; M'Vila, Ba, Camara; Pepe, Fortounis, Masouras
Man City: Ederson; Cancelo, Dias, Stones, Mendy; Foden, Rodri, GündoÄan; Sterling, Agüero, Silva
Man City: 2/7
Since City played Olympiacos at the start of the month, Guardiola’s side have drawn one – versus Liverpool – and lost one – against Tottenham. A brief break from the Premier League, against opposition that didn’t cause much trouble last time out, might just be exactly what City need. Expect them to respond positively here. Olympiacos 0-2 Man City.