What to watch: NFL Week 5 preview, schedule, live streams

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KANSAS CITY, MISSOURI - JANUARY 24: Josh Allen #17 of the Buffalo Bills attempts to pass the ball as he is pressured by Anthony Hitchens #53 of the Kansas City Chiefs in the first half during the AFC Championship game at Arrowhead Stadium on January 24, 2021 in Kansas City, Missouri. (Photo by Jamie Squire/Getty Images)
Josh Allen and the Buffalo Bills will look to exact some revenge on the Kansas City Chiefs for last year's AFC Championship loss in Week 5. (Photo by Jamie Squire/Getty Images)

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Another week down in the 2021-22 NFL season, and once again the weekend was filled with late-game heroics … or doinks (sorry, Patriots fans).

Through the first four weeks of the season, 15 games have had the winning points scored in the final minute of regulation or overtime, which is the most the league has seen in the last 50 years.

And with 16 games on the schedule for the last time until late in the season — teams begin to take their byes in Week 6 — there are sure to be a few more in Week 5.

Here are three matchups we think you should keep an extra close eye on when Sunday rolls around:

Cleveland Browns vs. Los Angeles Chargers

Sunday, Oct. 10 at 4:05PM ET | Live Stream

Spread: Pick'em

Over/Under Total: 49.5

Interest is always high when two of the top units on either side of the ball go head-to-head, and when the Browns head to SoFi stadium to take on the Chargers, that is exactly what you will get.

The Cleveland defence looks elite, led by their dominant front four including Myles Garrett who currently leads the league in sacks with six. The Browns "D" ranks as a top-three unit in both rushing and passing yards allowed, and has given up just 11.3 points per game over its past three contests.

Minnesota Vikings quarterback Kirk Cousins was completely stymied over the weekend, scoring just 7 points. However, this week the test gets that much more difficult as they take on Justin Herbert and the Chargers who just put on a show Monday night against the then-undefeated Las Vegas Raiders. 

Herbert has shown that his breakout rookie season was no fluke, picking up right where he left off in his second year. He is top-10 in both passing yards and passing touchdowns while leading the Chargers to a 3-1 start.  

On the flip side of the ball, the Browns need to try and get their passing offence back on track. Against the Vikings, Mayfield completed just 15-of-33 attempts for 155 yards, even with Odell Beckam Jr. back in the fold. Cleveland's run game is still its strength, with Nick Chubb and Kareem Hunt leading the way, but if the Browns want to truly compete with the top teams in the AFC come January, Mayfield and the aerial attack will need to be better. 

He better watch where he throws the ball on Sunday though, as the Chargers possess two young ball-hawks in safety Derwin James and rookie corner Asante Samuel Jr., who is looking more and more like his dad with each passing game. 

A win for either team would go a long way in solidifying themselves as a top-flight AFC contender. 

San Francisco 49ers vs. Arizona Cardinals

Sunday, Oct. 10 at 4:25PM ET | Live Stream

Spread: Cardinals -6.0

Over/Under Total: 50.0

Moneyline: 49ers (+205), Cardinals (-245)

If he wasn’t the MVP favourite coming into last week, Kyler Murray certainly is now. His dismantling of the Los Angeles Rams in their own building this past Sunday puts him at the head of the pack after four weeks.

Los Angeles looked to have no answer for the third-year quarterback, who constantly tormented them with his elusiveness in the pocket, converting multiple third-and-longs in the process. Murray has the uncanny ability to turn a play that originally looks destined for disaster into a positive for his team that so few quarterbacks in this league possess. He still might not be better at it than Patrick Mahomes — but this season, it’s definitely a conversation to be had.

But while Murray generates most of the highlights, the Cardinals defence should not go unmentioned. They were the first group who looked to really give the high-flying Rams offence problems, as Los Angeles quarterback Matthew Stafford seemed to look uncomfortable all game.

In Week 5, they face a new challenge, in that they may not know exactly who will be under centre for the opposition until just before game time. Jimmy Garoppolo — San Francisco’s starter for the first three weeks of the season — was forced to leave Week 4’s contest against the Seattle Seahawks at halftime with a calf injury, giving way to rookie Trey Lance.

Lance was solid in his first dose of consecutive meaningful snaps, finishing 9-of-18 for 157 yards and two touchdowns. He also brings a new element to the 49ers’ attack, as he ran 7 times for 41 yards after he took over for Garoppolo.

San Francisco head coach Kyle Shanahan said Monday that they have not ruled Garoppolo out just yet, with the team wanting to see how his leg reacts over a week of treatment. Trent Williams, their star left tackle who left Sunday with an injury of his own, also has a chance to play this week.

The timing of the injuries to two key players is less than ideal, as the 49ers will need all hands on deck to slow down Murray and the red-hot Cardinals, who are now the lone remaining undefeated team in the NFL. 

But could Lance being forced into action be just the thing the 49ers need to spark their season? We could find out this Sunday. 

Buffalo Bills vs. Kansas City Chiefs

Sunday, Oct. 10 at 8:20PM ET | Live Stream 

Spread: Chiefs -2.5

Over/Under Total: 56.5

Moneyline: Bills (+125), Chiefs (-145)

Remember when there were concerns about the Bills after their Week 1 loss to the Pittsburgh Steelers? Yeah, neither do we.

All Buffalo has done since is rip off three convincing wins, including last week’s 40-0 cakewalk against the Houston Texans. Yes, it is just the Texans, but in Week 2 they also shut out the Dolphins 35-0.

Josh Allen's offence has been impressive, but it’s the Bills defence that has really stood out through four weeks. They lead the league in both points (11.0) and yards (216.8) allowed per game, plus just a few other categories ...

In Week 4, the Bills forced Texans QB Davis Mills into four interceptions, and in Week 5 they will look to do the same to a quarterback with a slightly more distinguished pedigree. We are of course talking about Patrick Mahomes, who will lead the Chiefs into this marquee matchup in what is sure to be a rocking Arrowhead Stadium.

Mahomes and the Chiefs silenced any doubters in Week 4, putting up 42 on the Eagles including a casual 5 touchdown passed from the 26-year-old pivot. The Bills better have a better plan than the Eagles did when it comes to covering Tyreek Hill, as the speedster racked up 186 yards and three touchdowns in the City of Brotherly Love.

A lot of the headlines leading up to this one will probably revolve around the Bills looking for revenge from last year’s AFC Championship game when the Chiefs used a 21-point second quarter to send Buffalo packing.

But the Chiefs will also be feeling some pressure, as they come into the game last (yes, last) in their division at 2-2. All three other teams in the AFC West currently sit at 3-1, and a win on Sunday would catapult them right back into the driver's seat for the division crown.  

The only things standing in their way? A thriving Josh Allen and a red-hot Bills defence.

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