Filip Hronek, Dylan Larkin and Michael Rasmussen scored in Detroit's third straight win. It was Hronek's fourth goal in his last three games, and Larkin got his ninth of the season, tying for the team lead.
Nashville had gone 4-0-1 over its last five games and won its last six meetings with Detroit. Kevin Lankinen stopped 26 shots in his first start in nearly two weeks, but the Predators were shut out for the second time this season.
The Red Wings committed 10 giveaways in the first period, but the Predators only had seven shots on goal.
Larkin scored at 4:09 of the second period, snapping a wrist shot past Lankinen's glove.
Nashville had a 5-on-3 power play midway through the period but Husso stopped four shots.
Rasmussen tacked on an empty-netter in the final minute of the third.
The Red Wings claimed goaltender Magnus Hellberg off waivers from the Seattle Kraken. Hellberg, 31, appeared in one game for Detroit last season and one for Ottawa this season. He didn't see any game action for Seattle. ... Nashville assigned F Zach Sanford to Milwaukee of the American Hockey League. ... Red Wings F Oskar Sundqvist played his 300th career game.
Predators: Host Colorado on Friday.
Red Wings: Host Arizona on Friday.
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Dana Gauruder, The Associated Press