Fantasy Injury Updates: Jay Ajayi, Matt Breida, Saquon Barkley, others RBs suffer injuries ahead of Week 6

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Last week saw a handful of important fantasy football RBs get injured. Here are the latest updates on Matt Breida, Saquon Barkley, Lamar Miller, and Kerryon Johnson and how they'll impact Week 6 fantasy waiver pickups and rankings.

Fantasy Injury Updates: Jay Ajayi, Matt Breida, Saquon Barkley, others RBs suffer injuries ahead of Week 6

Last week saw a handful of important fantasy football RBs get injured. Here are the latest updates on Matt Breida, Saquon Barkley, Lamar Miller, and Kerryon Johnson and how they'll impact Week 6 fantasy waiver pickups and rankings.

Jay Ajayi is our for the season after suffering a knee injury. Matt Breida suffered an ankle injury that could keep him out a little while, while talented rookies Saquon Barkley and Kerryon Johnson also got banged-up late in their games and could be impacted going forward. And, of course, Lamar Miller was active for the Texans on Sunday night, but he didn't play a snap. There's a lot of injury news to sift through, and fantasy football owners will want to keep pace with the latest updates to know about critical wavier wire pickups and start 'em, sit 'em decisions ahead of Week 6.

We'll be on top of all the latest NFL injuries throughout the week, so check back often for updates. You can also follow us on Twitter @SN_Fantasy .

Week 6 Rankings:
Quarterback | Running Back | Wide Receiver | Tight End | D/ST | Kicker

Jay Ajayi injury news

According to ESPN's Adam Schefter, Ajayi suffered a torn ACL and is going to be out for the rest of the season. The diagnosis came as a bit of a surprise, but the Eagles lead back will now miss the rest of the season.

With Ajayi out, the Eagles will likely turn to Wendell Smallwood as their lead back. Smallwood is one of our top waiver wire pickups this week, and he should be added in all formats. He and Corey Clement may eventually end up splitting time, but Smallwood is healthier than Clement right now and that could do a lot to earn him the job. Either player can be added, but Smallwood is the safer bet at the moment.

Matt Breida injury update

UPDATE: According to NBC Sports Bay Area's Matt Maiocco, Breida suffered a "mid-to-high ankle sprain." That will likely solidify this as at least a 1-2 week injury, so be prepared to be without Breida for at least a couple of weeks.

Breida left Sunday's win over the Cardinals after suffering an ankle injury. He didn't return to the contest, and according to ESPN's Nick Wagoner, Breida suffered an ankle sprain in the contest. While initial X-Rays came out negative, Breida did leave the stadium in a walking boot, and that will put his status in doubt for the coming weeks.

It seems probable that Breida will miss at least a week or two of action depending on the severity of the ankle sprain. The 49ers will likely approach this injury with caution, as they have no reason to rush Breida back given their 1-4 record. So, if you're a Breida owner, you may be without him for a couple of weeks.

Should Breida miss time, Alfred Morris would become the lead back for the 49ers. Morris operated as the front-end of the team's one-two punch at RB to start the season before ceding snaps to Breida. He doesn't have much upside as a receiver, but with a high-volume of carries and TD potential, there's a chance he could be an RB2 moving forward. That's why he's one of our top waiver wire options for Week 6. Try to grab him if you can.

MORE: Full Week 6 waiver wire list | RB handcuff chart

Saquon Barkley injury news

UPDATE: Barkley apparently had a "random back spasm" per ESPN's Jordan Raanan, so he should be fine for Thursday night. Still, keep an eye on him as back injuries can sometimes be tricky.

Late in the game against the Panthers, Barkley hurdled a Carolina defender and came down awkwardly as he landed in the end zone. He initially stayed on the ground and was in a bit of pain, but he was able to get up and jog off to the sideline. According to ESPN's Jordan Raanan, Barkley "felt a little something in his back" but he expects to be fine.

This injury doesn't sound like a major issue for Barkley, but it's still something to keep an eye on should something tighten up in his back on a short week. In the event that Barkley is unable to be ready for Thursday night, Wayne Gallman would see the role as the lead back for the Giants. Against a tougher Eagles run defense, he wouldn't be more than a speculative FLEX play, but he might be worth adding if Barkley's injury is worse than it initially appeared.

Is Lamar Miller playing in Week 6?

UPDATE: According to Aaron Wilson of the Houston Chronicle, Miller is expected to play in Week 6. He was just available on an emergency basis for Sunday's game, but with a week of rest under his belt, he should be okay to go.

The Texans pulled a strange move on Sunday night that frustrated many fantasy football owners. Despite Miller being active for the team's game against the Cowboys, he didn't play. Miller, who was dealing with a chest injury, may be out longer term than many expected, but it's still confusing why the Texans elected to suit him up only to have him sit out the contest.

With Miller out, Alfred Blue handled a majority of the workload and totaled 119 scrimmage yards on 28 touches. He wasn't great between the tackles, but the volume opportunities are going to be there for him if Miller is out. Feel free to target him as a potential top handcuff/replacement for Miller, as he'll be a fringe RB2 in the event that Miller misses any time or loses his starting job.

The sneakier Texans back to keep an eye on is D'Onta Foreman. He's coming off a torn Achilles' from last season, and he's eligible to come off the PUP list in Week 7. That said, his overall health and status is unknown, so it may be best to wait another week before adding him to the roster, as there could be an update on him as his potential activation date draws nearer.

Kerryon Johnson injury update

Johnson suffered an ankle injury in the Lions win over the Packers and had to leave the game. After the game, he told ESPN's Michael Rothstein that he was "fine," and that's a good sign. With a bye week on the horizon for Johnson, it seems likely that he will have ample time to recover from this minor injury and still make it back to the field.

If Johnson is banged up and the Lions look to limit his snaps, that means LeGarrette Blount and Theo Riddick would get more touches. Still, it seems likely that Johnson will be fine, so unless something changes about his injury diagnosis, there isn't much to worry about here.

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