Powell and Leonard were vital players in the Raptors' successful championship run four years ago. This was Leonard's second game in Toronto with the Clippers (21-15) since the title.
Powell received a standing ovation when honoured by the home team with a video scoreboard tribute during a first-quarter timeout.
Trent scored 20, while Scottie Barnes was good for a double-double of 18 points and 13 rebounds.
After hitting a season-high 19 three-point jumpers in their win in Cleveland last Friday, the Raptors managed only six with 23 attempts against Los Angeles.
The Clippers pulled away in the third quarter, leading by as much as 18 points but settled for a 97-82 lead.
The Raptors chipped away at the Clippers' lead, pulling to within 13 points with 5:23 remaining. But Los Angeles dug in to finish off their opponents.
The Clippers enjoyed a 60-56 advantage at halftime in a back-and-forth opening two quarters that saw the game tied seven times and 13 lead changes.
George continued his fine play. He checked in with 32 points in the Clippers' 142-131 overtime win in Detroit against the Pistons on Monday and poured in 15 more points in the first half and 21 in total.
Leading the way for the Raptors, who enjoyed a 29-27 lead after the first quarter, was Trent with 14 first-half points, two better than O.G. Anunoby.
Raptors head coach Nick Nurse was asked if Leonard influenced Siakam's work ethic in the former's only season with Toronto.
"Pascal and I'd even throw Fred in there right now, two guys who it just doesn't matter what's going on, they're there early in the morning," Nurse said.
"It doesn't matter how many games we've played or where we've come from. They understand this is what it is. It isn't a sometimes thing. It's a day-in, day-out process. I think those guys learned that from (Leonard)."
This report by The Canadian Press was first published Dec. 27, 2022.
Tim Wharnsby, The Canadian Press