Jahlil Jenkins and Kaleb Bishop made successive layups to put the Knights up 50-47 with 9:55 remaining. But Moore sandwiched a layup and a 3-pointer between a Romeo Weems layup that started a 14-2 run and Fairleigh Dickinson never recovered.
The Blue Demons (3-0) played their third game in four nights. DePaul scored 19 points off 21 Fairleigh Dickinson (1-1) turnovers. Jaylen Butz added 13 points for DePaul.
Jenkins scored had 17 points for the Knights (1-1), and Elyjah Williams and Bishop each scored 12.
DePaul plays at Iowa on Monday and Fairleigh Dickinson travels to Fordham Wednesday.
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Elements of this story were generated by Automated Insights, http://www.automatedinsights.com/ap, using data from STATS LLC, https://www.stats.com