2021
| Date | Home/Away | Opponent | Status | Score |
|---|
| @ |  Illinois | L | 30 - 22 |
| vs | Fordham | W | 52 - 7 |
| vs | Buffalo | W | 28 - 3 |
| @ | (16) Oklahoma | L | 23 - 16 |
| @ | (10) Michigan St. | L | 23 - 20 |
| vs | Northwestern | W | 56 - 7 |
| vs | (2) Michigan | L | 32 - 29 |
| @ | Minnesota | L | 30 - 23 |
| | Bye Week | | |
| vs | Purdue | L | 28 - 23 |
| vs | (6) Ohio St. | L | 26 - 17 |
| @ | Wisconsin | L | 35 - 28 |
| vs | (15) Iowa | L | 28 - 21 |
| East Division | CONF | OVR | PF | PA |
|---|
| 8-1 | 12-2 | 501 | 243 |
| 8-1 | 11-2 | 594 | 296 |
| 7-2 | 11-2 | 414 | 329 |
| 4-5 | 7-6 | 325 | 225 |
| 3-6 | 7-6 | 381 | 399 |
| 2-7 | 5-8 | 256 | 333 |
| 0-9 | 2-10 | 207 | 399 |
| West Division | CONF | OVR | PF | PA |
|---|
| 7-2 | 10-4 | 328 | 269 |
| 6-3 | 9-4 | 331 | 225 |
| 6-3 | 9-4 | 378 | 291 |
| 6-3 | 9-4 | 330 | 210 |
| 4-5 | 5-7 | 242 | 263 |
| 1-8 | 3-9 | 199 | 348 |
| 1-8 | 3-9 | 335 | 272 |
