| | P | Sent to Minors (The Houston Astros optioned RHP Dylan Coleman to the minors.) |
| | CF | Sent to Minors (The Houston Astros sent OF Quincy Hamilton to the minors.) |
| | C | Sent to Minors (The Houston Astros sent C Luke Berryhill to the minors.) |
| | CF | Sent to Minors (The Houston Astros optioned OF Kenedy Corona to the minors.) |
| | P | Sent to Minors (The Houston Astros sent RHP Misael Tamarez to the minors.) |
| | P | Sent to Minors (The Houston Astros optioned RHP Forrest Whitley to the minors.) |
| | P | Sent to Minors (The Houston Astros sent RHP Ray Gaither to the minors.) |
| | P | Sent to Minors (The Houston Astros sent RHP Spencer Arrighetti to the minors.) |
| | 1B | Sent to Minors (The Houston Astros sent INF Chris Gittens to the minors.) |
| | SS | Sent to Minors (The Houston Astros sent INF Dixon Machado to the minors.) |
| | CF | Sent to Minors (The Houston Astros sent OF Jacob Melton to the minors.) |
| | SS | Sent to Minors (The Houston Astros sent INF Zach Dezenzo to the minors.) |
| | C | Sent to Minors (The Houston Astros sent C Miguel Palma to the minors.) |
| | P | Sent to Minors (The Houston Astros sent RHP A.J. Blubaugh to the minors.) |
| | P | Sent to Minors (The Houston Astros sent RHP Rhett Kouba to the minors.) |
| | P | Sent to Minors (The Houston Astros sent LHP Colton Gordon to the minors.) |
| | 2B | Sent to Minors (The Houston Astros sent INF Will Wagner to the minors.) |
| | P | Signed (The Houston Astros signed RHP Conner Greene to a minor league contract.) |
| | P | Released (The Houston Astros released LHP Brailyn Marquez.) |
| | | Traded (The San Diego Padres traded OF Oliver Carrillo to the Houston Astros.) From |
| | 2B | Signed (The Houston Astros signed INF Jeremy Arocho to a minor league contract.) |
| | 2B | Signed (The Houston Astros signed INF Jeremy Arocho to a minor league contract.) |
| | P | Waived (The Houston Astros waived RHP Declan Cronin.) |
| | 1B | Traded (The Los Angeles Angels traded OF Trey Cabbage to the Houston Astros.) From |
| | P | Designated for Assignment (The Houston Astros designated RHP Declan Cronin for assignment.) |
| | | Traded (The Houston Astros traded RHP Carlos Espinosa to the Los Angeles Angels.) To |
| | P | Non-roster Invitee (The Houston Astros invited RHP Drew Strotman to spring training.) |
| | P | Signed (The Houston Astros signed RHP Drew Strotman to a minor league contract.) |
| | P | Signed (The Houston Astros signed RHP Drew Strotman to a minor league contract.) |
| | P | Signed (The Houston Astros signed LHP Josh Hader.) |
| | P | Designated for Assignment (The Houston Astros designated LHP Matt Gage for assignment.) |
| | SS | Non-roster Invitee (The Houston Astros invited INF Zach Dezenzo to spring training.) |
| | P | Sent to Minors (The Houston Astros sent RHP Joel Kuhnel outright to the minors.) |
| | P | Claimed on Unconditional Release Waivers (The Houston Astros claimed RHP Declan Cronin off waivers from the Chicago White Sox.) |
| | 1B | Signed (The Houston Astros signed INF Chris Gittens to a minor league contract.) |
| | 1B | Signed (The Houston Astros signed INF Chris Gittens to a minor league contract.) |
| | P | Designated for Assignment (The Houston Astros designated RHP Joel Kuhnel for assignment.) |
| | P | Signed (The Houston Astros signed RHP Wander Suero to a minor league contract.) |
| | C | Signed (The Houston Astros signed C Victor Caratini.) |
| | P | Signed (The Houston Astros signed RHP Wander Suero to a minor league contract.) |
| | P | Traded (The Kansas City Royals traded RHP Dylan Coleman to the Houston Astros.) From |
| | P | Traded (The Houston Astros traded RHP Carlos Mateo to the Kansas City Royals.) To |
| | P | Signed (The Houston Astros signed LHP Brailyn Marquez to a minor league contract.) |
| | P | Signed (The Houston Astros signed LHP Brailyn Marquez to a minor league contract.) |
| | SS | Signed (The Houston Astros signed INF Jesús Bastidas to a minor league contract.) |
| | CF | Recalled From Minors Rehab (The Houston Astros selected the contract of OF Kenedy Corona from the minors.) |
| | P | Declared Free Agency ( RHP Matt Ruppenthal declared free agency.) |
| | P | Declared Free Agency (RHP Ronny Garcia declared free agency.) |
| | P | Declared Free Agency (RHP Joe Record declared free agency.) |
| | P | Declared Free Agency (RHP Jake Cousins declared free agency.) |
| | P | Declared Free Agency (RHP Diosmerky Taveras declared free agency.) |
| | C | Declared Free Agency (C Garrett Wolforth declared free agency.) |
| | C | Declared Free Agency (C Andrew Knapp declared free agency.) |
| | 2B | Declared Free Agency (INF Rylan Bannon declared free agency.) |
| | 1B | Declared Free Agency (INF J.J. Matijevic declared free agency.) |
| | P | Declared Free Agency (RHP Enoli Paredes declared free agency.) |
| | P | Declared Free Agency (LHP Juan Lopez declared free agency.) |
| | P | Declared Free Agency (RHP Angel Macuare declared free agency.) |
| | P | Sent to Minors (The Houston Astros sent RHP Enoli Paredes outright to the minors.) |
| | P | Activated (The Houston Astros activated RHP Bryan Abreu.) |
| | P | Declared Free Agency (RHP Hector Neris elected free agency.) |
| | P | Activated (The Houston Astros activated LHP Bennett Sousa.) |
| | P | Activated (The Houston Astros activated RHP Lance McCullers.) |
| | P | Activated (The Houston Astros activated LHP Matt Gage.) |
| | P | Activated (The Houston Astros activated RHP Oliver Ortega.) |
| | LF | Activated (The Houston Astros activated OF Corey Julks.) |
| | P | Activated (The Houston Astros activated RHP Enoli Paredes.) |
| | P | Activated (The Houston Astros activated RHP Kendall Graveman.) |
| | P | Activated (The Houston Astros activated RHP Forrest Whitley.) |
| | C | Activated (The Houston Astros activated C César Salazar.) |
| | 2B | Activated (The Houston Astros activated INF David Hensley.) |
| | P | Activated (The Houston Astros activated LHP Parker Mushinski.) |
| | P | Activated (The Houston Astros activated RHP Seth Martinez.) |
| | P | Activated (The Houston Astros activated RHP Luis Garcia.) |
| | CF | Activated (The Houston Astros activated OF Jake Meyers.) |
| | P | Activated (The Houston Astros activated RHP Brandon Bielak.) |
| | P | Activated (The Houston Astros activated RHP Shawn Dubin.) |
| | P | Activated (The Houston Astros activated RHP Joel Kuhnel.) |
| | P | Declared Free Agency (Houston Astros RHP Phil Maton declared free agency.) |
| | DH | Declared Free Agency (Houston Astros DH Michael Brantley declared free agency.) |
| | P | Declared Free Agency (Houston Astros RHP Ryne Stanek declared free agency.) |
| | C | Declared Free Agency (Houston Astros C Martín Maldonado declared free agency.) |
| | P | Claimed on Unconditional Release Waivers (The Houston Astros claimed RHP Oliver Ortega off waivers from the Minnesota Twins.) |
| | P | Starting to Serve Suspension (Major League Baseball suspended RHP Bryan Abreu for two games.) |
| | CF | Sent to Minors (The Houston Astros optioned OF Jake Meyers to the minors.) |
| | P | Recalled From Minors Rehab (The Houston Astros recalled RHP Ronel Blanco from the minors.) |
| | RF | Declared Free Agency (OF Bligh Madris declared free agency.) |
| | P | Sent to Minors (The Houston Astros optioned LHP Bennett Sousa to the minors.) |
| | P | Sent to Minors (The Houston Astros optioned RHP Kendall Graveman to the minors.) |
| | P | Sent to Minors (The Houston Astros optioned RHP Seth Martinez to the minors.) |
| | P | Activated (The Houston Astros activated RHP Ryne Stanek from the paternity list.) |
| | P | Recalled From Minors Rehab (The Houston Astros recalled RHP Seth Martinez from the minors.) |
| | P | Placed on Paternity Leave List (The Houston Astros placed RHP Ryne Stanek on the Paternity Leave list.) |
| | P | Activated (The Houston Astros activated RHP Ryne Stanek from the 15-day injured list.) |
| | P | Sent to Minors (The Houston Astros optioned RHP Joel Kuhnel to the minors.) |
| | P | Recalled From Minors Rehab (The Houston Astros recalled LHP Bennett Sousa from the minors.) |
| | P | Sent to Minors (The Houston Astros optioned LHP Parker Mushinski to the minors.) |
| | P | Recalled From Minors Rehab (The Houston Astros recalled LHP Parker Mushinski from the minors.) |
| | 2B | Sent to Minors (The Houston Astros sent INF Rylan Bannon outright to the minors.) |
| | P | Placed on 15-Day IL (The Houston Astros placed RHP Ryne Stanek on the 15-day injured list.) |
| | P | Claimed on Unconditional Release Waivers (The Houston Astros claimed LHP Bennett Sousa off waivers from the Detroit Tigers.) |
| | 2B | Designated for Assignment (The Houston Astros designated INF Rylan Bannon for assignment.) |
| | P | Released (The Houston Astros released LHP Nick Allgeyer.) |
| | P | Sent to Minors (The Houston Astros sent RHP Jake Cousins outright to the minors.) |
| | SS | Activated (The Houston Astros activated INF Grae Kessinger from the 10-day injured list.) |
| | P | Recalled From Minors Rehab (The Houston Astros recalled RHP Joel Kuhnel from the minors.) |
| | DH | Activated (The Houston Astros activated DH Michael Brantley from the 60-day injured list.) |
| | P | Designated for Assignment (The Houston Astros designated RHP Jake Cousins for assignment.) |
| | LF | Sent to Minors (The Houston Astros optioned OF Corey Julks to the minors.) |
| | P | Activated (The Houston Astros activated RHP Phil Maton from the 15-day injured list.) |
| | P | Sent to Minors (The Houston Astros optioned RHP Ronel Blanco to the minors.) |
| | P | Sent to Minors (The Houston Astros optioned RHP Brandon Bielak to the minors.) |
| | P | Recalled From Minors Rehab (The Houston Astros recalled RHP Ronel Blanco from the minors. ) |
| | P | Recalled From Minors Rehab (The Houston Astros recalled RHP Brandon Bielak from the minors.) |
| | P | Sent to Minors (The Houston Astros optioned RHP Seth Martinez to the minors.) |
| | 2B | Sent to Minors (The Houston Astros optioned INF David Hensley to the minors.) |
| | 1B | Activated (The Houston Astros activated INF José Abreu from the 10-day injured list.) |
| | P | Recalled From Minors Rehab (The Houston Astros recalled RHP Seth Martinez from the minors.) |
| | P | Sent to Minors (The Houston Astros optioned LHP Parker Mushinski to the minors.) |
| | SS | Placed on 10-Day IL (The Houston Astros placed INF Grae Kessinger on the 10-day injured list.) |
| | LF | Recalled From Minors Rehab (The Houston Astros recalled OF Corey Julks from the minors.) |