| P | 15-day-dl (The Cleveland Guardians placed RHP Eli Morgan on the 15-day injured list with right shoulder inflammation.) | |
| P | 15-day-dl (The Cleveland Guardians placed RHP Shane Bieber on the 15-day injured list with a season ending elbow injury.) | |
| 2B | 60-day-dl (The Cleveland Guardians placed INF Angel Martínez on the 10-day injured list.) | |
| P | 15-day-dl (The Cleveland Guardians placed RHP Gavin Williams on the 15-day injured list.) | |
| P | 60-day-dl (The Cleveland Guardians placed RHP Trevor Stephan on the 60-day injured list.) | |
| P | 60-day-dl (The Cleveland Guardians placed RHP James Karinchak on the 60-day injured list.) | |
| P | 15-day-dl (The Cleveland Guardians placed LHP Sam Hentges on the 15-day injured list.) | |