| Player | Wins |
|---|---|
| Cy Young | 511 |
| Walter Johnson | 417 |
| Pete Alexander | 373 |
| Christy Mathewson | 373 |
| Warren Spahn | 363 |
| Pud Galvin | 360 |
| Kid Nichols | 360 |
| Greg Maddux | 355 |
| Roger Clemens | 354 |
| Tim Keefe | 342 |
| John Clarkson | 329 |
| Steve Carlton | 329 |
| Eddie Plank | 326 |
| Nolan Ryan | 324 |
| Don Sutton | 324 |
| Phil Niekro | 318 |
| Gaylord Perry | 314 |
| Tom Seaver | 311 |
| Old Hoss Radbourn | 309 |
| Mickey Welch | 308 |
| Tom Glavine | 305 |
| Randy Johnson | 303 |
| Early Wynn | 300 |
| Lefty Grove | 300 |
| Tommy John | 288 |
| Bert Blyleven | 287 |
| Tony Mullane | 287 |
| Robin Roberts | 286 |
| Fergie Jenkins | 284 |
| Jim Kaat | 283 |
| Red Ruffing | 273 |
| Mike Mussina | 270 |
| Burleigh Grimes | 270 |
| Jamie Moyer | 269 |
| Jim Palmer | 268 |
| Bob Feller | 266 |
| Eppa Rixey | 266 |
| Jim McCormick | 265 |
| Gus Weyhing | 265 |
| Ted Lyons | 260 |
| Andy Pettitte | 256 |
| Red Faber | 254 |
| Jack Morris | 254 |
| Carl Hubbell | 253 |
| Bob Gibson | 251 |
| Vic Willis | 248 |
| Amos Rusie | 248 |
Bartolo Colon* | 247 |
| Jack Quinn | 247 |
| Joe McGinnity | 246 |
CC Sabathia* | 246 |
| Dennis Martinez | 245 |
| Jack Powell | 244 |
| Juan Marichal | 243 |
| Herb Pennock | 241 |
| Frank Tanana | 240 |
| David Wells | 239 |
| Three Finger Brown | 239 |
| Waite Hoyt | 237 |
| Whitey Ford | 236 |
| Clark Griffith | 236 |
| Charlie Buffinton | 233 |
| Luis Tiant | 229 |
| Will White | 229 |
| Sad Sam Jones | 229 |
| George Mullin | 227 |
| Catfish Hunter | 224 |
| Jim Bunning | 224 |
| Mel Harder | 223 |
| Paul Derringer | 223 |
| Hooks Dauss | 222 |
| Tim Hudson | 222 |
| Jerry Koosman | 222 |
| Joe Niekro | 221 |
| Jerry Reuss | 220 |
| Pedro Martinez | 219 |
| Kenny Rogers | 219 |
| Earl Whitehill | 218 |
| Bob Caruthers | 217 |
| Freddie Fitzsimmons | 217 |
| Mickey Lolich | 217 |
| Curt Schilling | 216 |
| Wilbur Cooper | 216 |
| Charlie Hough | 216 |
| Stan Coveleski | 215 |
| Jim Perry | 215 |
| Rick Reuschel | 214 |
| Mark Buehrle | 214 |
| John Smoltz | 213 |
| Chief Bender | 212 |
| Bob Welch | 211 |
| Bobo Newsom | 211 |
| Billy Pierce | 211 |
| Kevin Brown | 211 |
| Jesse Haines | 210 |
| Don Drysdale | 209 |
| Milt Pappas | 209 |
| Vida Blue | 209 |
| Eddie Cicotte | 209 |
| Bob Lemon | 207 |