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Week 16 Over/Under: The DeMarco dilemma, can you trust Murray?

Fantasy is a speculative game. Predict the future, and you look like a genius. Don't, and you're painfully human. Gazing into the crystal ball, here's our view on 10 intriguing over/unders for Week 16.

Assuming he's active, project DeMarco Murray's line (atts-rush yds-recs-receiving yds-tds) at home vs. Indy. 

Dalton – 19 attempts, 90 rushing yards, 2 receptions, 12 yards, 1 touchdown

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Scott – 17 attempts, 83 rushing yards, 1 reception, 7 yards, 1 touchdown

Brad – 15 attempts, 79 rushing yards, 0 receptions, 0 touchdowns

Ben Roethlisberger, who's averaged an otherworldly 373.3 passing yards per game and totaled 20 touchdowns in six home games this year, fantasy points scored vs. KC 17.5. 

Andy – OVER, barely. It's not the greatest of matchups, as the Chiefs defense ranks second in the league in terms of passing yards allowed. But KC has also given up 21 touchdown passes while only collecting four interceptions. Ben has so many weapons at his disposal and he's been a monster at home, so I'll trust him here.

Brandon – UNDER. In Yahoo default scoring, Big Ben has topped this number five times while the KC defense has allowed this number just three times. In fact, KC hasn't let a QB reach 270 passing yards, and it has faced six top 10 fantasy QBs, to date. If I'm playing the odds, they are telling me, in no uncertain terms, to take the under.

Dalton – OVER. You’ve already pointed out how good he’s been at home this season, and while Kansas City has yielded the second-fewest fantasy points to opposing QBs this season, that’s been accompanied by a 21:4 TD:INT ratio. KC has countered that by allowing an NFL-low two touchdowns on the ground, which should result in a nice game from Big Ben.

[Week 16 rankings: Quarterback | Running Back | Receiver | Tight End | Kicker | DST]

Saturday Special. Coming off an inexplicable zero-catch game against Dallas, Jordan Matthews receptions against woeful Washington 5.5. 

Brandon –  UNDER. I can see him catching four or five passes, but six is a bit of reach given that Philly has really dialed down QB Mark Sanchez's pass attempts (under 30 in each of the past three games). While Washington's secondary is exploitable, I'm not sure it's going to be that lucrative for Philly given that it's a road game against a divisional foe that can put serious pressure on the QB. I'm guessing Chip Kelly will once again try to keep things conservative for Sanchez.

Dalton – OVER. Since Mark Sanchez took over QB duties (when Mathews became fantasy relevant), the rookie wideout has averaged 5.2 catches while hailing in four scores, and that modest reception average comes with him totaling just two over the past two contests combined. This week he’s facing a Washington secondary that’s surrendered the fifth-most fantasy points to opposing WRs this season, so expect him to bounce back from the recent slump.

Brad – OVER. Last week was a fluke fanatics. Washington is dreadfully, woefully, terribly bad against the pass. Would be no shocker if the rookie duplicated his 8-59-2 line against 'Skins back in Week 3.

Julius Thomas, who has one catch to his name since Week 12, receiving yards on the road in Cincinnati 44.5.  BONUS: Will he score a TD YES or NO? 

Dalton – UNDER. Even over the first five games in which he scored a remarkable nine touchdowns, he averaged just 55.4 receiving yards. Thomas has averaged 29.8 yards in the six games he’s played since, and now he’s also dealing with a hobbled Peyton Manning. Still, despite playing in just 11 games (and being extremely limited in others), he’s somehow still tied for second in the NFL with 12 TD catches, so I’m saying YES he scores Sunday.

Andy – UNDER and YES. I'm not expecting heavy usage from Thomas, a player whose value is almost exclusively tied to touchdowns. He's caught just 41 balls for 456 yards on the year, yet he's given us 12 spikes. In a tricky matchup at Cincinnati, I'll give him four catches for 41 yards and one score.

Scott – I'm not a fan of expecting much from injury returnees, but Thomas had his feet-wet game last week, This week, back to full deployment. The Bengals pass defense is better on the flanks against the wideouts; I'll give Thomas an affirmative OVER and YES to these assignments.

Josh Gordon, who hasn't rewarded the patient, receiving yards with Johnny Failure Football under center in Carolina 64.5. 

Andy – Um ... no. No. UNDER. I just can't do it, not after last week's Manziel meltdown. If you're starting Gordon, you're simply hoping for a score. Within the context of last week's game, it's plenty impressive that Gordon delivered 48 receiving yards. I don't think I can make myself project more than 60 at this point.

Scott – Have to take the UNDER. Johnny Football didn't look close to ready last week and Gordon isn't in top form yet, either.

Dalton – OVER. Johnny Manziel’s first game was one of the worst I’ve ever seen, yet Gordon somehow managed 48 receiving yards against a Bengals team that’s allowed the second fewest fantasy points to opposing wideouts this season. Johnny Football gets another week of first-team practice reps, and Gordon gets an easier matchup. But I have to say I’m not optimistic about JFF’s future.

Marshawn Lynch, who hasn't eclipsed the century mark in combined yardage in four straight meetings versus Arizona, total yards the fifth time around 99.5. 

Brad – UNDER. This game has 9-6 written all over it. Lynch will be sporadically useful, but considering RBs are averaging under 3.5 yards per carry in 'Zona since Week 1 last year and given his recent history versus the Desert Birds, the Beast falls short of 100.

Andy – UNDER, but not by much. It's not as if Lynch has been a complete dud against the Cards. He's still a good bet for a touchdown and, say, 80-ish yards.

Brandon – UNDER. Yeah, Arizona is legitimately tough on opposing running backs. I think Beast-Mode will find the end zone, but I suspect he'll wind up in the 70-80-yard range. Should be a serviceable fantasy day for Lynch, just don't count on 100 yards.

RGIII, once again back in the saddle with Colt McCoy sidelined, total yards Saturday against Philadelphia 274.5.   

Brandon  – OVER. I'm sticking with my early-week fearless forecast of 248 passing yards and 40 rushing yards, which I think is very doable against a Philly defense allowing the fourth-most passing yards and rushing yards to the QB position.

Scott – UNDER, since that's such a big number. Griffin's stubbed his toe too many times in 2013-2014 for me to start him aggressively. That said, the Philly defense has made a slew of mediocre QBs look good, and I do think it will be a competitive game. I have Griffin in the QB2 range this week, not a Top 10er.

Brad – OVER. Jay Gruden's public shots at RGIII continue to paint the passer as a mental midget. His flawed on-field fundamentals certainly supports that. Still, the Eagles are allowing 299.9 combined yards per game to slingers. On a high volume, Griffin meanders his way to 280-plus with 1-2 touchdowns.

If Julio Jones is deemed inactive, Harry Douglas receiving yards in 'Nawlins 99.5.  

Dalton – UNDER. I like Douglas as a WR2/3 in fantasy leagues if Julio Jones is out in a game that’s over/under is 56 points, but Douglas has averaged 68.2 yards in “starts” this year and has reached 100 in just two games all season.

Brad – OVER. Sean Payton instituted major defensive changes last week, which proved wondrous last week in Chicago. Still, his secondary is far from lock-down. Assuming no Julio, Douglas is sure to surpass the 100-yard mark for the second straight week. Keep in mind Vegas projects a scoring bonanza (55.5 over/under).

Scott – UNDER. I know the Vegas receiving props aren't hashed out with depth, since the handle is low, but I'm positive it will be considerably lower than this. And to the side, remember the rub with Douglas: he's not a big touchdown guy. He has 406 career catches and a piddly eight touchdowns.

OLD MAN STRENGTH! Fred Jackson, who goes toe-to-toe with the rancid Raiders, standard fantasy points scored this Sunday 12.9. 

Brad – OVER. The Raiders reek, especially defending the run. In total, 12 RBs have eclipsed the propsed number this year. Jackson, even with C.J. Spiller possibly in uniform, is a strong bet for 80-90 total yards and a TD.

Dalton – OVER. C.J. Spiller may return in some capacity this week, but Jackson is coming off a four game stretch in which he’s either gained at least 97 yards, scored or saw 14 targets. He now faces an Oakland front seven this week that’s ceded the second-most fantasy most to opposing running backs this year.

Brandon – OVER. There have been 12 running backs that have eclispsed this mark against the Raiders this season, and if Jackson gets the 22 touches that he has averaged over the past three games, I don't see how he doesn't become the 13th RB to topple this number.

Top-Five Buys. Your best bets (versus the spread or over/unders) for Week 15.

Brandon – 1) WAS +7.5, vs. Phi, 2) SDG-SF over 41 3) TB +12 vs. GB 4) CAR -3.5 vs. Cle 5) DET -8 at CHI

Dalton – 1) DEN -3 at Cin, 2) HOU +5 vs Bal, 3) SF -1 vs. SD 4) CAR -3.5 vs. Cle 5) OAK +7 vs. Buf

Scott –  1) WAS +7.5, 2) DEN -3, 3) OAK +7, 4) STL-NYG under 43, 5) DEN-CIN under 47.5

Brad – 1) OVER GB/TB 48.5, 2) Pit (-3) vs. KC, 3) Ari (+7.5) vs. Sea, 4) UNDER Den/Cin 47.5, 5) SF (-1) vs. SD

Andy – 1) DET -8 at CHI, 2) HOU +5 vs. BAL, 3) WAS +7.5 vs. PHI, 4) SF -1 vs. SD, 5) GB-TB Over 48.5

Want to bull rush Brad? Find him on Twitter. Also, check out the Yahoo! Fantasy and Rotoworld crew every Tuesday-Thursday on 'Fantasy Football Live' starting at 6:30 PM ET on NBC Sports Network (Find channel here). Additionally, tune into 'FFL' radio on Yahoo! Sports Radio Sundays at 9 AM ET.