| Date | Player | Position | Transaction |
|---|---|---|---|
| Nov 20 | Robert Manuel | RP | Acquired off waivers from Seattle to Boston |
| Nov 18 | George Kottaras | C/3B | Acquired off waivers from Boston to Milwaukee |
| Nov 16 | George Kottaras | C/3B | Released by Boston |
| Nov 13 | Paul Byrd | SP | Declared free agency by Boston |
| Nov 13 | Chris Woodward | 3B/SS/2B | Declared free agency by Boston |
| Nov 11 | Jason Varitek | C | Signed by Boston (exercised player option) |
| Nov 11 | Fernando Cabrera | RP | Refused minor league assignment - free agent by Boston |
| Nov 9 | Álex González | SS | Declared free agency by Boston (team option declined) |
| Nov 9 | Víctor Martínez | C/1B | Signed by Boston (team option exercised) |
| Nov 9 | Tim Wakefield | SP | Signed by Boston (two-year extension) |
| Nov 7 | Joey Gathright | CF/LF/RF | Refused minor league assignment - free agent by Boston |
| Nov 6 | Miguel González | RP | Outrighted to minors by Boston |
| Nov 5 | Jeremy Hermida | RF/LF | Traded from Florida to Boston (for LHPs Hunter Jones & Jose Alvarez) |
| Nov 5 | Hunter Jones | RP | Traded from Boston to Florida (w/LHP Jose Alvarez for OF Jeremy Hermida) |
| Nov 5 | Nick Green | SS/2B/3B/LF | Outrighted to minors by Boston |
| Nov 5 | Fernando Cabrera | RP | Outrighted to minors by Boston |
| Nov 5 | Joey Gathright | CF/LF/RF | Outrighted to minors by Boston |
| Nov 5 | Rocco Baldelli | RF/CF/LF/3B | Declared free agency by Boston |
| Nov 5 | Jason Bay | LF | Declared free agency by Boston |
| Nov 5 | Billy Wagner | RP | Declared free agency by Boston |
| Nov 5 | Nick Green | SS/2B/3B/LF | Refused minor league assignment - free agent by Boston |